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Hydrophilic interaction liquid chromatography: An update

McCalley, David V.

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Abstract

This article is an update on the technique of hydrophilic interaction liquid chromatography (HILIC) and covers recent ideas on the mechanism of separation, and how it may be manipulated to suit the separation of particular sample types. The advantages of HILIC are discussed, and also the actual and perceived disadvantages of the technique, and how the latter can be overcome. Some new applications of HILIC in the characterization of pharmaceuticals , where it can be applied even to the separation of intact proteins, and to applications in metabolomics, will be discussed.

Journal Article Type Article
Publication Date Mar 1, 2019
Journal LC.GC Europe
Print ISSN 1471-6577
Peer Reviewed Peer Reviewed
Volume 32
Issue 3
Pages 114-125
APA6 Citation McCalley, D. V. (2019). Hydrophilic interaction liquid chromatography: An update. Lc Gc Europe, 32(3), 114-125
Keywords high performance liquid chromatography, drugs, biopharmaceuticals, hydrophilic interactions
Publisher URL http://www.chromatographyonline.com/hydrophilic-interaction-liquid-chromatography-update
Additional Information Additional Information : This is the author's accepted manuscript. The final published version is available here: http://www.chromatograp...d-chromatography-update

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