Outputs (396)

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices (2017)
Journal Article

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the desig... Read More about Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices.

Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology: Implications for Alzheimer's disease (2017)
Journal Article

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. A major risk factor for the development of Alzheimer's disease (AD) is increasing age, but the reason behind this association has not been identified. It is thought that the changes in... Read More about Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology: Implications for Alzheimer's disease.

The effect of hypoxia on alternative splicing in prostate cancer cell lines (2017)
Thesis

Hypoxia is defined as the state in which the availability or delivery of oxygen is insufficient to meet tissue demand. It occurs particularly in aggressive, fast-growing tumours in which the rate of new blood vessel formation (angiogenesis) cannot ma... Read More about The effect of hypoxia on alternative splicing in prostate cancer cell lines.

The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory (2017)
Journal Article

© 2017 The Author(s). Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate... Read More about The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory.

Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia (2017)
Thesis

Alternative splicing of pre-mRNA is a ubiquitous and versatile mechanism controlling the expression of human genes. In humans, approximately 93% of multi-exonic genes are alternatively spliced, producing functionally distinct proteins. Dysregulation... Read More about Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia.

Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data (2017)
Journal Article

© 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. Acoustic surveys of bats are one of the techniques most commonly used by ecological practitioners. The results are used in Ecological Impact Assessments to assess the lik... Read More about Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data.

Understanding and manipulating the separation in hydrophilic interaction liquid chromatography (2017)
Journal Article

© 2017 Elsevier B.V. Hydrophilic interaction liquid chromatography (HILIC) has emerged as a valuable complimentary technique to reversed-phase (RP), being especially suited for the analysis of polar and ionised solutes, which are difficult to retain... Read More about Understanding and manipulating the separation in hydrophilic interaction liquid chromatography.

The in situ bacterial production of fluorescent organic matter; An investigation at a species level (2017)
Journal Article

© 2017 The Authors Aquatic dissolved organic matter (DOM) plays an essential role in biogeochemical cycling and transport of organic matter throughout the hydrological continuum. To characterise microbially-derived organic matter (OM) from common env... Read More about The in situ bacterial production of fluorescent organic matter; An investigation at a species level.

Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species (2017)
Journal Article

© 2017 Elsevier B.V. Cacao swollen shoot virus is a member of the family Caulimoviridae, genus Badnavirus and is naturally transmitted to Theobroma cacao (L.) by several mealybug species. CSSV populations in West African countries are highly variable... Read More about Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species.

Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances (2017)
Journal Article

© 2017 Hartill, Szymanska, Sharif, Wheway and Johnson. Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary... Read More about Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances.

Mild external heating and reduction in spontaneous contractions of the bladder (2017)
Journal Article

© 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd Objectives: To measure the effect of external heating on bladder wall contractile function, histological structure and expression of proteins related t... Read More about Mild external heating and reduction in spontaneous contractions of the bladder.

Conservation strategies for understanding and combating the primate bushmeat trade on Bioko Island, Equatorial Guinea (2017)
Journal Article

© 2017 Wiley Periodicals, Inc. Bioko Island, Equatorial Guinea is among the important places in Africa for the conservation of primates, but a cultural preference for bushmeat and a lack of effective law enforcement has encouraged commercial bushmeat... Read More about Conservation strategies for understanding and combating the primate bushmeat trade on Bioko Island, Equatorial Guinea.

Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line (2017)
Journal Article

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc... Read More about Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line.

Assessing the antimicrobial potential of aerosolised electrochemically activated solutions (ECAS) for reducing the microbial bio-burden on fresh food produce held under cooled or cold storage conditions (2017)
Journal Article

© 2017 The main aim of this study was to assess the antimicrobial efficacy of electrochemically activated fog (ECAF) for reducing the microbial bio-burden on artificially inoculated fresh produce held under cooled (cucumber and vine tomatoes) or cold... Read More about Assessing the antimicrobial potential of aerosolised electrochemically activated solutions (ECAS) for reducing the microbial bio-burden on fresh food produce held under cooled or cold storage conditions.

A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors (2017)
Journal Article

© 2017 Elsevier B.V. This paper describes the development of a novel electrochemical assay for the measurement of water-soluble vitamins in food and pharmaceutical products. The optimum conditions for the determination of vitamin B1 (thiamine), B2 (r... Read More about A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors.

Signaling through the primary cilium (2018)
Journal Article

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remainin... Read More about Signaling through the primary cilium.

Experimentally manipulating light spectra reveals the importance of dark corridors for commuting bats (2018)
Journal Article

© 2018 The Authors Global Change Biology Published by John Wiley & Sons Ltd The rapid global spread of artificial light at night is causing unprecedented disruption to ecosystems. In otherwise dark environments, street lights restrict the use of ma... Read More about Experimentally manipulating light spectra reveals the importance of dark corridors for commuting bats.

Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL (2017)
Journal Article

© 2017 Elsevier Inc. The normal cellular role of α-synuclein is of potential importance in understanding diseases in which an aggregated form of the protein has been implicated. A potential loss or change in the normal function of α-synuclein could p... Read More about Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.

Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma (2017)
Thesis

Multiple myeloma (MM) is a haematological malignancy characterized by terminally differentiated plasma cells and their accumulation in the bone marrow (BM). Despite significant advances in therapeutic strategies it currently remains incurable. The in... Read More about Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma.

Cell biology (2017)
Book Chapter

There is no abstract