Signaling through the primary cilium

Wheway, Gabrielle; Nazlamova, Liliya; Hancock, John T

doi:10.3389/fcell.2018.00008

Signaling through the primary cilium

Wheway, Gabrielle; Nazlamova, Liliya; Hancock, John T

Authors

Gabrielle Wheway Gabrielle.Wheway@uwe.ac.uk
Occasional Associate Lecturer - CHSS - DAS

Liliya Nazlamova

John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling

Abstract

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term "the cells's antenna" as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the "ciliopathies" resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.

Journal Article Type	Review
Acceptance Date	Jan 23, 2018
Publication Date	Feb 8, 2018
Deposit Date	Jan 23, 2018
Publicly Available Date	Jan 23, 2018
Journal	Frontiers in Cell and Developmental Biology
Electronic ISSN	2296-634X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	6
Issue	FEB
DOI	https://doi.org/10.3389/fcell.2018.00008
Keywords	signaling, cilium, ciliopathies, development, developmental signaling, signaling pathways, ciliary signaling
Public URL	https://uwe-repository.worktribe.com/output/876478
Publisher URL	http://dx.doi.org/10.3389/fcell.2018.00008
Additional Information	Additional Information : This Document is protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Contract Date	Jan 23, 2018