Outputs (564)

Investigation and verification of a bioluminescent biosensor for the quantitation of ara-CTP generation: A biomarker for cytosine arabinoside sensitivity in acute myeloid leukaemia (2014)
Journal Article

A novel whole cell bacterial biosensor, which emits light in response to the active metabolite of cytosine arabinoside (ara-C, cytarabine), ara-CTP, has been investigated and verified. The biosensor has been formulated as an ex vivo assay, designed f... Read More about Investigation and verification of a bioluminescent biosensor for the quantitation of ara-CTP generation: A biomarker for cytosine arabinoside sensitivity in acute myeloid leukaemia.

Antimicrobial susceptibility and time-kill analysis of single and combined essential oil blends against clinical and non-clinical isolates of bacteria and fungi (2014)
Presentation / Conference Contribution

The continued emergence of antibiotic resistant bacteria and infection outbreaks in healthcare and community settings has created a need for development of new antibiotics and exploration of alternative therapeutics. Essential oils (EOs) have been id... Read More about Antimicrobial susceptibility and time-kill analysis of single and combined essential oil blends against clinical and non-clinical isolates of bacteria and fungi.

A review of the volatiles from the healthy human body (2014)
Journal Article

A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urin... Read More about A review of the volatiles from the healthy human body.

Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance (2013)
Journal Article

The coagulation of blood plasma and the effect of fibrinogen concentration were studied with a quartz crystal microbalance (QCM), where frequency and half-width at half-maximum (bandwidth) values measured from the conductance spectrum near resonant f... Read More about Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance.

Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer (2014)
Journal Article

© American Society for Clinical Pathology. Objectives: To investigate the association between PTEN loss and IGFBP2 expression in a series of triple-negative breast cancers and to relate this expression to basal cytokeratin expression and clinicopatho... Read More about Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer.

Testing the effectiveness of surveying techniques in determining bat community composition within woodland (2014)
Journal Article

Context Determining the biodiversity of an area is essential for making targeted conservation decisions. Undertaking surveys to confirm species presence or to estimate population sizes can be difficult, particularly for elusive species. Bats are able... Read More about Testing the effectiveness of surveying techniques in determining bat community composition within woodland.

The modulatory effects of commensal neisseriae on upper respiratory tract infections
Thesis

The human nasopharynx is a reservoir of both commensal and pathogenic bacteria that can be easily transmitted from one individual to another. It has long been hypothesised that host commensal flora give protection from carriage of pathogens and invas... Read More about The modulatory effects of commensal neisseriae on upper respiratory tract infections.

Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing (2014)
Journal Article

Composites of WO3 nanoparticles and water-soluble polyaniline (PANI) particles doped with dodecyl benzenesulphonic acid at different mass ratios were deposited onto interdigitated electrodes and characterised using electrochemical impedance spectrosc... Read More about Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing.

The use of transposon libraries to investigate the evolution of bacterial pathogenesis (2014)
Thesis

Pseudomonas syringae pathovar phaseolicola (Pph) is the seed borne causative agent of halo blight disease in the common bean, Phaseolus vulgaris. Gene-for-gene interactions are widespread and a very important aspect of plant disease resistance. Pph r... Read More about The use of transposon libraries to investigate the evolution of bacterial pathogenesis.

Effect of pressure on the selectivity of polymeric C18 and C30 stationary phases in reversed-phase liquid chromatography. Increased separation of isomeric fatty acid methyl esters, triacylglycerols, and tocopherols at high pressure (2014)
Journal Article

A high-density, polymeric C18 stationary phase (Inertsil ODS-P) or a polymeric C30 phase (Inertsil C30) provided improved resolution of the isomeric fatty acids (FAs), FA methyl esters (FAMEs), triacylglycerols (TAGs), and tocopherols with an increas... Read More about Effect of pressure on the selectivity of polymeric C18 and C30 stationary phases in reversed-phase liquid chromatography. Increased separation of isomeric fatty acid methyl esters, triacylglycerols, and tocopherols at high pressure.

Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs (2014)
Journal Article

The cumulative effects of dietary arginine, leucine and protein levels on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig longissimus lumborum muscle and subcutaneous adipose tissue (SAT) were investig... Read More about Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs.

Exploring the computational potential of simple chemical reactions
Thesis

A large number of human activities rely on conventional computing devices producing huge quantities of data. These “traditional computers” may eventually fail to deal with such demands. Therefore, there is a need to develop novel computing paradigms,... Read More about Exploring the computational potential of simple chemical reactions.

Simulation of three dimensional double-diffusive throughflow in internally heated anisotropic porous media (2014)
Journal Article

A model for double-diffusive convection in an anisotropic porous layer with a constant throughflow is explored, with penetrative convection being simulated via an internal heat source. The validity of both the linear instability and global nonlinear... Read More about Simulation of three dimensional double-diffusive throughflow in internally heated anisotropic porous media.

Modelling of blood component flexibility using quartz crystal microbalance (2014)
Journal Article

Quartz crystal microbalance (QCM) is a sensitive technique for real-time monitoring of cell adsorption, aggregation and cell-to-surface interaction processes. However, cell adhesion time courses are usually considered as merely qualitative, being pre... Read More about Modelling of blood component flexibility using quartz crystal microbalance.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl (2014)
Journal Article

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive... Read More about Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl.

The branched-chain aminotransferase proteins: Novel redox chaperones for protein disulfide isomerase-implications in Alzheimer's disease (2014)
Journal Article

Aims: The human branched-chain aminotransferase proteins (hBCATm and hBCATc) are regulated through oxidation and S-nitrosation. However, it remains unknown whether they share common redox characteristics to enzymes such as protein disulfide isomerase... Read More about The branched-chain aminotransferase proteins: Novel redox chaperones for protein disulfide isomerase-implications in Alzheimer's disease.

The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands (2014)
Thesis

A novel lipid modifying enzyme, lysophosphatidylcholine acyltransferase (LPCAT), has been shown to regulate pro-inflammatory cytokine responses to lipopolysaccharide (LPS), a key molecule in initiating sepsis. Current research has shown that phosphol... Read More about The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands.

Microbial acetone oxidation in coastal seawater (2014)
Journal Article

Acetone is an important oxygenated volatile organic compound (OVOC) in the troposphere where it influences the oxidizing capacity of the atmosphere. However, the air-sea flux is not well quantified, in part due to a lack of knowledge regarding which... Read More about Microbial acetone oxidation in coastal seawater.

24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation (2014)
Journal Article

Vitamin D receptor (VDR) agonists supporting human osteoblast (hOB) differentiation in the absence of bone resorption are attractive agents in a bone regenerative setting. One potential candidate fulfilling these roles is 24,25-dihydroxy vitamin D3 (... Read More about 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation.

The relationship between growth stages and aroma composition of lemon basil Ocimum citriodorum Vis (2014)
Journal Article

Volatiles from infusions of lemon basil Ocimum citriodorum Vis were evaluated by SPME-GC/MS. Citral, linalool and estragole were the major constituents. Citral, the major contributor to the lemony flavour, was significantly higher in post-flowering (... Read More about The relationship between growth stages and aroma composition of lemon basil Ocimum citriodorum Vis.