Dr Helen Sanderson's Outputs (4)

A mitotic role for BRCA1/BARD1 in tumor suppression? (2006)
Journal Article

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase... Read More about A mitotic role for BRCA1/BARD1 in tumor suppression?.

Cell biology: Ran, mitosis and the cancer connection (2006)
Journal Article

The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer. © 2006 Elsevier Ltd. All rights... Read More about Cell biology: Ran, mitosis and the cancer connection.

Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export (2006)
Journal Article

The nuclear pore complex (NPC) conducts macromolecular transport to and from the nucleus and provides a kinetic/hydrophobic barrier composed of phenylalanine-glycine (FG) repeats. Nuclear transport is achieved through permeation of this barrier by tr... Read More about Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.

High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis (2006)
Journal Article

Nuclear pore complexes (NPCs) are the gateways for both active and passive bidirectional molecular transport between the nucleoplasm and cytoplasm. These mega-dalton assemblies are composed of multiple copies of approximately 30 distinct proteins ter... Read More about High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis.