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All Outputs (864)

Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome (2013)
Journal Article

Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the de... Read More about Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome.

Adherence therapy following an acute episode of schizophrenia: A multi-centre randomised controlled trial (2013)
Journal Article

Background: Non-adherence with antipsychotic medication is common in patients with schizophrenia. Aims: To establish the efficacy of adherence therapy (AT) compared to treatment as usual (TAU) in improving medication compliance in patients following... Read More about Adherence therapy following an acute episode of schizophrenia: A multi-centre randomised controlled trial.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids (2013)
Journal Article

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of cancer. Importantly, PGE2 is reported to enhance Wnt/β-catenin signalling in colorectal carcino... Read More about LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids.

Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay (2013)
Journal Article

The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activ... Read More about Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Engaging a wider public health workforce for the future: A public health practitioner in residence approach (2013)
Journal Article

This paper outlines and assesses a project that sought to use a studio residency (a public health practitioner in residence) as a vehicle to introduce public health issues and concepts into the curricula of a studio cohort of fifth and sixth year arc... Read More about Engaging a wider public health workforce for the future: A public health practitioner in residence approach.

Money, commodification and complementary health care: Theorising personalised medicine within depersonalised systems of exchange (2013)
Journal Article

Across the United Kingdom and other Western nations, complementary health care has become big business, with pressure to commercialise and technologise its goods and services. Economic liberalisation and the democratisation of health care have encour... Read More about Money, commodification and complementary health care: Theorising personalised medicine within depersonalised systems of exchange.

Rewards can be used effectively with repeated exposure to increase liking of vegetables in 4-6-year-old children (2013)
Journal Article

Abstract Objective To examine whether parents offering a sticker reward to their child to taste a vegetable the child does not currently consume is associated with improvements in children's liking and consumption of the vegetable. Design A randomize... Read More about Rewards can be used effectively with repeated exposure to increase liking of vegetables in 4-6-year-old children.

The counter-terrorism provisions of the protection of freedoms Act 2012: Preventing misuse or a case of smoke and mirrors? (2013)
Journal Article

The article examines the provisions of the Protection of Freedoms Act 2012 dealing with the maximum length of detention without trial in terrorism cases, and stop and search under the Terrorism Act 2000. It considers whether the government's objectiv... Read More about The counter-terrorism provisions of the protection of freedoms Act 2012: Preventing misuse or a case of smoke and mirrors?.

Temperature response of denitrification rate and greenhouse gas production in agricultural river marginal wetland soils (2013)
Journal Article

Soils are predicted to exhibit significant feedback to global warming via the temperature response of greenhouse gas (GHG) production. However, the temperature response of hydromorphic wetland soils is complicated by confounding factors such as oxyge... Read More about Temperature response of denitrification rate and greenhouse gas production in agricultural river marginal wetland soils.