All Outputs (135)

Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease (2019)
Journal Article

© 2019 - IOS Press and the authors. All rights reserved. Background: Differential diagnosis of people presenting with mild cognitive impairment (MCI) that will progress to Alzheimer's disease (AD) remains clinically challenging. Current criteria used... Read More about Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease.

Visitor from another star (2019)
Journal Article

Asteroid, comet, alien ship or something else altogether? Astronomers are still unsure about the true nature of 'Oumuamua – the first confirmed interstellar object to be detected in our solar system – as Andrew Glester finds

The antimicrobial effect of a commercial mixture of natural antimicrobials against Escherichia coli O157:H7 (2019)
Journal Article

Ruminants are important reservoirs of E. coli O157:H7 and are considered as the major source of most foodborne outbreaks (e.g., 2017 outbreak in Germany, 2014 and 2016 outbreaks in United States, all linked to beef products). A promising strategy to... Read More about The antimicrobial effect of a commercial mixture of natural antimicrobials against Escherichia coli O157:H7.

Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Investigations into novel electrochemical technology for boar taint detection and vitamin analysis (2019)
Thesis

This thesis presents the evaluation of the novel electrochemical sensor and biosensor technology developed for the direct analysis of boar taint compounds in adipose tissue (European Patent 2966441). Gas chromatographic methods and extraction procedu... Read More about Investigations into novel electrochemical technology for boar taint detection and vitamin analysis.

An evidence-based approach to specifying survey effort in ecological assessments of bat activity (2019)
Journal Article

Robust ecological assessments are fundamental for effective wildlife conservation. Owing to the high legal protection of bats, surveys are frequently required as part of ecological assessments. Yet there is uncertainty about the amount of survey effo... Read More about An evidence-based approach to specifying survey effort in ecological assessments of bat activity.

Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms’ tumor suppressor Wt1 (2019)
Journal Article

Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations. Although VEGF is overexpressed in most tumors,... Read More about Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms’ tumor suppressor Wt1.

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells (2019)
Journal Article

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia patients; ho... Read More about LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder (2019)
Journal Article

Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The... Read More about Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder.

Imaging autophagy in hiPSC-derived midbrain dopaminergic neuronal cultures for Parkinson’s disease research (2019)
Book Chapter

To appreciate the positive or negative impact of autophagy during the initiation and progression of human diseases, the isolation or de novo generation of appropriate cell types is required to support focused in vitro assays. In human neurodegenerati... Read More about Imaging autophagy in hiPSC-derived midbrain dopaminergic neuronal cultures for Parkinson’s disease research.

Evidencing impact: a case study of UK academic perspectives on evidencing research impact (2019)
Journal Article

© 2017, © 2017 Society for Research into Higher Education. The principle that research should demonstrate impact is now a central driver in UK research policy, with some describing the UK as having undergone a ‘culture change’ in regards to evidencin... Read More about Evidencing impact: a case study of UK academic perspectives on evidencing research impact.

The role of redox in signal transduction (2019)
Book Chapter

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Story-oriented learning (2019)
Presentation / Conference Contribution

In a game environment, narrative design is considered the art of combining gameplay and multimedia assets to create novel experiences that can entertain players and motivate them for longer periods. The use of narrative design in game-driven educatio... Read More about Story-oriented learning.

Climate change and insectivore ecology (2019)
Book Chapter

The impacts of climate change on natural populations are only beginning to be understood. Although some important changes are already occurring, in the future these are predicted to be more substantial and of greater ecological significance. Insects... Read More about Climate change and insectivore ecology.