All Outputs (128)

Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons (2023)
Journal Article

The principles of evidence-based medicine (EBM) are the foundation of modern medical practice. Surgeons are familiar with the commonly used statistical techniques to test hypoth-eses, summarize findings, and provide answers within a specified range o... Read More about Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons.

NOTCH and AKT signalling interact to drive mammary tumour heterogeneity (2023)
Journal Article

A better understanding of the mechanisms generating tumour heterogeneity will allow better targeting of current therapies, identify potential resistance mechanisms and highlight new approaches for therapy. We have previously shown that in genetically... Read More about NOTCH and AKT signalling interact to drive mammary tumour heterogeneity.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method (2023)
Journal Article

In this study, liposomes enclosing eugenol were prepared using microfluidics. Two lipids—1,2-dimyristoyl-sn-glycero-3-phosphocholine, 18:0 (DSPC) and 2-dimyristoyl-sn-glycero-3-phosphocholine, 14:0 (DMPC)—and microfluidic chips with serpentine and Y-... Read More about The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method.

Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry (2023)
Journal Article

A liquid chromatography-tandem mass spectrometry screening method in sweat was developed for the simultaneous determination of three licit drugs (nicotine, paracetamol, and caffeine); four illicit drugs (cocaine, ketamine, 25I-NBOMe and methamphetami... Read More about Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry.

Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds (2023)
Journal Article

With the rapidly expanding global nuclear industry, more efficient and direct radiological monitoring approaches are needed to ensure the associated environmental health impacts and risk remain fully assessed and undertaken as robustly as possible. C... Read More about Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds.

Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources (2023)
Journal Article

It is estimated that the world will need an extra 265 million tons of protein by the middle of this century, which is approximately 50 % more than today. Efforts are currently underway to find sustainable protein sources for keepin... Read More about Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Ventilatory efficiency is reduced in people with hypertension during exercise (2023)
Journal Article

BACKGROUND: An elevated ventilatory efficiency slope during exercise (minute ventilation/volume of expired CO2; VE /VCO2 slope) is a strong prognostic indicator in heart failure. It is elevated in people with heart failure with preserved ejection, ma... Read More about Ventilatory efficiency is reduced in people with hypertension during exercise.

Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow (2023)
Journal Article

Donor cell leukaemia (DCL) is a complication of haematopoietic stem cell transplantation where donated cells become malignant within the patient's bone marrow. As DCL predominates as acute myeloid leukaemia, we hypothesized that the cytokine storm fo... Read More about Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow.

Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails (2022)
Journal Article

Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unus... Read More about Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails.

Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens (2022)
Journal Article

Despite the identification of the high-incidence red cell antigen Era nearly 40 years ago, the molecular background of this antigen, together with the other 2 members of the Er blood group collection, has yet to be elucidated. Whole exome and Sanger... Read More about Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens.

Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development (2022)
Journal Article

Burkholderia have potential as biocontrol agents because they encode diverse biosynthetic gene clusters (BGCs) for a range of antimicrobial metabolites. Given the opportunistic pathogenicity associated with Burkholderia species, heterologous BGC expr... Read More about Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development.

COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage (2022)
Journal Article

The COVID-19 pandemic changed continuous positive airway pressure (CPAP) setup pathways. We evaluated patients commenced on CPAP in 2019 (prepandemic) and 2020 (post-first UK wave). Face-to-face (F2F) setup numbers, with CPAP turned on, decreased fro... Read More about COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage.

In silico analyses of maleidride biosynthetic gene clusters (2022)
Journal Article

Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined... Read More about In silico analyses of maleidride biosynthetic gene clusters.

Radioactivity in future phosphogypsum: New predictions based on estimates of ‘Peak P’ and rock phosphate resources (2022)
Journal Article

Global food supplies currently depend on producing inorganic P fertilisers from a finite reserve of rock phosphate (RP). P fertilisers are themselves significant pollutants but their production from RP also leaves a phosphogypsum (PG) by-product that... Read More about Radioactivity in future phosphogypsum: New predictions based on estimates of ‘Peak P’ and rock phosphate resources.

The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder (2021)
Journal Article

Purpose: The urinary bladder generates phasic contractions via action potentials generated in pre- and then postganglionic neurons. Whilst the frequency-dependence of postganglionic neurons to generate contractions has been quantified, the dynamic ra... Read More about The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder.

Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model (2021)
Journal Article

Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes B... Read More about Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model.

Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites (2021)
Journal Article

The use of filamentous fungi as cellular factories, where natural product pathways can be refactored and expressed in a host strain, continues to aid the field of natural product discovery. Much work has been done to develop host strains which are ge... Read More about Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites.

Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation (2020)
Journal Article

The effects of ionising radiation (IR) on plants are important for environmental protection but also in agriculture, horticulture, space science, and plant stress biology. Much current understanding of the effects of IR on plants derives from acute h... Read More about Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation.