An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Trakarnsanga, Kongtana; Griffiths, Rebecca E.; Wilson, Marieangela C.; Blair, Allison; Satchwell, Timothy J.; Meinders, Marjolein; Cogan, Nicola; Kupzig, Sabine; Kurita, Ryo; Nakamura, Yukio; Toye, Ashley M.; Anstee, David J.; Frayne, Jan

doi:10.1038/ncomms14750

All Outputs (4)

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis (2017)
Journal Article

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds... Read More about Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis.

CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex (2017)
Journal Article

CD47 is an important 'marker of self' protein with multiple isoforms produced though alternative splicing that exhibit tissue-specific expression. Mature erythrocytes express CD47 isoform 2 only, with membrane stability of this version dependent on i... Read More about CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex.

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion (2017)
Journal Article

Invasion of the red blood cell (RBC) by the Plasmodium parasite defines the start of malaria disease pathogenesis. To date, experimental investigations into invasion have focused predominantly on the role of parasite adhesins or signaling pathways an... Read More about Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion.

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells (2017)
Journal Article

With increasing worldwide demand for safe blood, there is much interest in generating red blood cells in vitro as an alternative clinical product. However, available methods for in vitro generation of red cells from adult and cord blood progenitors d... Read More about An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.