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Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line (2017)
Journal Article
Daly, C. S., Dean, S. J., Daly, C., Conway, M. E., Qualtrough, D., Shafei, M., & Flemban, A. (2018). Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line. Oncology Reports, 39(2), 483-490. https://doi.org/10.3892/or.2017.6125

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc... Read More about Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line.

A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7 (2015)
Journal Article
Dean, S. J., Perks, C. C., Rhodes, A., Holly, J. M., & Jarrett, C. (2015). A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7. American journal of biomedical sciences, 7(1), 15-25. https://doi.org/10.5099/aj150100015

Fatty acid binding protein 7 (FABP7) is a 15kDa protein that plays a role in fatty acid transport, solubilisation and metabolism. It has been found to be overexpressed in triple negative/basal like breast cancer patients. The role of FABP7 in these... Read More about A strategic approach for the visualisation of the low abundance protein fatty acid binding protein 7.

Triple negative breast cancer: The role of metabolic pathways (2014)
Journal Article
Dean, S. J., & Rhodes, A. (2014). Triple negative breast cancer: The role of metabolic pathways. Malaysian Journal of Pathology, 36(3), 155-162

The incidence of breast cancer in Malaysia and other Asian countries is on the increase, reflecting lifestyle changes some of which are known risk factors for the development of breast cancer. Most breast cancers are amenable to adjuvant therapies th... Read More about Triple negative breast cancer: The role of metabolic pathways.

Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer (2014)
Journal Article
Koobotse, M. O., Holly, J. M., Perks, C. M., Dean, S. J., Dean, S. J., Perks, C., …Rhodes, A. (2014). Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer. American Journal of Clinical Pathology, 141(3), 323-333. https://doi.org/10.1309/AJCPR11DEAYPTUSL

© American Society for Clinical Pathology. Objectives: To investigate the association between PTEN loss and IGFBP2 expression in a series of triple-negative breast cancers and to relate this expression to basal cytokeratin expression and clinicopatho... Read More about Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer.

An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo (2014)
Thesis
Dean, S. J. An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo. (Thesis). University of the West of England

Introduction Triple negative breast cancers are defined by their lack of expression of HER, oestrogen receptors and progesterone receptors. They account for around 10-24% of cases. To define a cancer by the biomarkers it does not express is unsati... Read More about An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo.