All Outputs (261)

Evolving multi-valued regulatory networks on tuneable fitness landscapes (2023)
Journal Article

Random Boolean networks have been used widely to explore aspects of gene regulatory networks. As the name implies, traditionally the model has used a binary representation scheme. This paper uses a modified form of the model to systematically explore... Read More about Evolving multi-valued regulatory networks on tuneable fitness landscapes.

A generalised dropout mechanism for distributed systems (2022)
Journal Article

This letter uses a modified form of the NK model introduced to explore aspects of distributed control. In particular, a previous result suggesting the use of dynamically formed subgroups within the overall system can be more effective than global con... Read More about A generalised dropout mechanism for distributed systems.

A haploid-diploid evolutionary algorithm optimizing nanoparticle based cancer treatments (2022)
Book Chapter

This paper uses a recent explanation for the fundamental haploid-diploid lifecycle of eukaryotic organisms to present a new evolutionary algorithm that differs from all previous known work using diploid representations. A form of the Baldwin effect h... Read More about A haploid-diploid evolutionary algorithm optimizing nanoparticle based cancer treatments.

Nonbinary representations in the NK and NKCS models (2022)
Journal Article

The NK model has been used widely to explore aspects of natural evolution and complex systems. Traditionally, the model has used a binary representation scheme. This paper introduces a modified form of the NK model through which to systematically exp... Read More about Nonbinary representations in the NK and NKCS models.

Evolving Boolean regulatory networks with variable gene expression times (2021)
Book Chapter

The time taken for gene expression varies not least because proteins vary in length considerably. This paper uses an abstract, tuneable Boolean regulatory network model to explore gene expression time variation. In particular, it is shown how non-uni... Read More about Evolving Boolean regulatory networks with variable gene expression times.

Evolutionary algorithms designing nanoparticle cancer treatments with multiple particle types (2021)
Journal Article

There is a rich history of evolutionary algorithms tackling optimization problems where the most appropriate size of solutions, namely the genome length, is unclear a priori. Here, we investigated the applicability of this methodology on the problem... Read More about Evolutionary algorithms designing nanoparticle cancer treatments with multiple particle types.

On coevolution: Asymmetry in the NKCS model (2021)
Journal Article

The NKCS model was introduced to explore coevolutionary systems, that is, systems in which multiple species are closely interconnected. The fitness landscapes of the species are coupled to a controllable amount, where the underlying properties of the... Read More about On coevolution: Asymmetry in the NKCS model.

On the emergence of intersexual selection: Arbitrary trait preference improves female-male coevolution (2021)
Journal Article

Sexual selection is a fundamental aspect of evolution for all eukaryotic organisms with mating types. This article suggests intersexual selection is best viewed as a mechanism with which to compensate for the unavoidable dynamics of coevolution betwe... Read More about On the emergence of intersexual selection: Arbitrary trait preference improves female-male coevolution.

Autoencoding with a classifier system (2021)
Journal Article

Autoencoders are data-specific compression algorithms learned automatically from examples. The predominant approach has been to construct single large global models that cover the domain. However, training and evaluating models of increasing size com... Read More about Autoencoding with a classifier system.

Are artificial dendrites useful in neuro-evolution? (2021)
Journal Article

The significant role of dendritic processing within neuronal networks has become increasingly clear. This letter explores the effects of including a simple dendrite-inspired mechanism into neuro-evolution. The phenomenon of separate dendrite activati... Read More about Are artificial dendrites useful in neuro-evolution?.

Metameric representations on optimization of nano particle cancer treatment (2021)
Journal Article

In silico evolutionary optimization of cancer treatment based on multiple nano-particle (NP) assisted drug delivery systems was investigated in this study. The use of multiple types of NPs is expected to increase the robustness of the treatment, due... Read More about Metameric representations on optimization of nano particle cancer treatment.

Supplementary material: Evolutionary algorithms designing nano particle cancer treatments with multiple particle types (2021)
Other

Supplementary material: Evolutionary algorithms designing nano particle cancer treatments with multiple particle types

In silico optimization of cancer therapies with multiple types of nanoparticles applied at different times (2020)
Journal Article

© 2020 The Author(s) Background and Objective: Cancer tumors constitute a complicated environment for conventional anti-cancer treatments to confront, so solutions with higher complexity and, thus, robustness to diverse conditions are required. Alter... Read More about In silico optimization of cancer therapies with multiple types of nanoparticles applied at different times.

The Evolution of Complexity: Simple Simulations of Major Innovations (2020)
Book

Novelty search employed into the development of cancer treatment simulations (2020)
Journal Article

Conventional optimization methodologies may be hindered when the automated search is stuck into local optima because of a deceptive objective function landscape. Consequently, open ended search methodologies, such as novelty search, have been propose... Read More about Novelty search employed into the development of cancer treatment simulations.

Exploring distributed control with the NK model (2020)
Journal Article

The NK model has been used widely to explore aspects of natural evolution and complex systems. This paper introduces a modified form of the NK model for exploring distributed control in complex systems such as organisations, social networks, collecti... Read More about Exploring distributed control with the NK model.

Towards an evolvable cancer treatment simulator (2019)
Journal Article

© 2019 Elsevier B.V. The use of high-fidelity computational simulations promises to enable high-throughput hypothesis testing and optimisation of cancer therapies. However, increasing realism comes at the cost of increasing computational requirements... Read More about Towards an evolvable cancer treatment simulator.

Design mining microbial fuel cell cascades (2018)
Journal Article

Microbial fuel cells (MFCs) perform wastewater treatment and electricity production through the conversion of organic matter using microorganisms. For practical applications, it has been suggested that greater efficiency can be achieved by arranging... Read More about Design mining microbial fuel cell cascades.

The evolution of sex through the Baldwin effect (2017)
Journal Article

This paper suggests that the fundamental haploid-diploid cycle of eukaryotic sex exploits a rudimentary form of the Baldwin effect. With this explanation for the basic cycle, the other associated phenomena can be explained as evolution tuning the amo... Read More about The evolution of sex through the Baldwin effect.

On Design Mining: Coevolution and Surrogate Models (2017)
Journal Article

© 2017 Massachusetts Institute of Technology. Published under a Creative Commons Attribution 3.0 Unported (CC BY 3.0) license. Design mining is the use of computational intelligence techniques to iteratively search and model the attribute space of ph... Read More about On Design Mining: Coevolution and Surrogate Models.