Michail Tsompanas Antisthenis.Tsompanas@uwe.ac.uk
Lecturer in Computer Science
Michail Tsompanas Antisthenis.Tsompanas@uwe.ac.uk
Lecturer in Computer Science
Lawrence Bull Larry.Bull@uwe.ac.uk
School Director (Research & Enterprise) and Professor
Andrew Adamatzky Andrew.Adamatzky@uwe.ac.uk
Professor
Igor Balaz
Igor Balaz
Editor
Andrew Adamatzky Andrew.Adamatzky@uwe.ac.uk
Editor
This paper uses a recent explanation for the fundamental haploid-diploid lifecycle of eukaryotic organisms to present a new evolutionary algorithm that differs from all previous known work using diploid representations. A form of the Baldwin effect has been identified as inherent to the evolutionary mechanisms of eukaryotes and a simplified version is presented here which maintains such behaviour. Using a well-known abstract tuneable model, it is shown that varying fitness landscape ruggedness varies the benefit of haploid-diploid algorithms. Moreover, the methodology is applied to optimise the targeted delivery of a therapeutic compound utilizing nano-particles to cancerous tumour cells with the multicellular simulator PhysiCell.
Online Publication Date | Aug 12, 2022 |
---|---|
Publication Date | 2022 |
Deposit Date | Feb 9, 2023 |
Publicly Available Date | Aug 13, 2024 |
Publisher | Springer |
Pages | 237-251 |
Series Title | Part of the Emergence, Complexity and Computation book series (ECC, Volume 46) |
Series Number | 2194-7287; 2194-7295 |
Edition | 1st |
Book Title | Cancer, Complexity, Computation |
Chapter Number | 10 |
ISBN | 9783031043789 |
DOI | https://doi.org/10.1007/978-3-031-04379-6_10 |
Keywords | Baldwin; effect; diploid; NK model; cancer; nano-particles; PhysiCell |
Public URL | https://uwe-repository.worktribe.com/output/10442865 |
Publisher URL | https://link.springer.com/chapter/10.1007/978-3-031-04379-6_10 |
Related Public URLs | https://link.springer.com/book/10.1007/978-3-031-04379-6 /> https://www.springer.com/series/10624 |
This file is under embargo until Aug 13, 2024 due to copyright reasons.
Contact Antisthenis.Tsompanas@uwe.ac.uk to request a copy for personal use.
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