A novel in vitro flat-bed perfusion biofilm model for determining the potential antimicrobial efficacy of topical wound treatments

Thorn, Robin; Greenman, J.

doi:10.1111/j.1365-2672.2009.04398.x

Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality (2018)
Journal Article

Objectives: These studies aimed to assess the short-term (12-hour, single use) and long-term (four weeks, continuous use) efficacy of a new Dual Zinc plus Arginine dentifrice against intra-oral halitosis versus a negative control. Methods: Two cl... Read More about Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality.

Synthesis and bactericidal properties of porphyrins immobilized in a polyacrylamide support: Influence of metal complexation on photoactivity (2017)
Journal Article

© The Royal Society of Chemistry. Spectroscopic and photodynamic properties of three novel polymeric hydrogels bearing porphyrins have been studied in vitro on the recombinant bioluminescent Gram-negative Escherichia coli DH5α to assess their ability... Read More about Synthesis and bactericidal properties of porphyrins immobilized in a polyacrylamide support: Influence of metal complexation on photoactivity.

Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized cross-over clinical investigation (2016)
Journal Article

Abstract The objective of this clinical investigation was to test the effectiveness on breath odor of a newly designed sonic tongue brush (TongueCare+, TC). It consists of a soft silicone brush optimally designed based on the tongue's anatomy t... Read More about Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized cross-over clinical investigation.

Analysis of microbial fuel cell operation in acidic conditions using the flocculating agent ferric chloride (2016)
Journal Article

© 2014 Society of Chemical Industry. BACKGROUND: Ferric chloride (FeCl3) is widely used as a flocculating agent during wastewater treatment but can detrimentally lower pH and increase iron concentration. Microbial fuel cells (MFCs) are a promising te... Read More about Analysis of microbial fuel cell operation in acidic conditions using the flocculating agent ferric chloride.

Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria (2016)
Journal Article

© 2016 The Royal Society of Chemistry. In 2013, the World Health Organization reported that 884 million people lack access to clean potable water. Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiot... Read More about Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria.

Volatiles from oral anaerobes confounding breath biomarker discovery (2013)
Journal Article

The levels of compounds in exhaled mouth air do not necessarily reflect levels in the systemic circulation as bacteria can bio-transform substrates to produce compounds within the mouth. This should be of concern to researchers measuring breath volat... Read More about Volatiles from oral anaerobes confounding breath biomarker discovery.

The first self-sustainable microbial fuel cell stack (2013)
Journal Article

This study reports for the first time on the development of a self-sustainable microbial fuel cell stack capable of self-maintenance (feeding, hydration, sensing & reporting). Furthermore, the stack system is producing excess energy, which can be use... Read More about The first self-sustainable microbial fuel cell stack.

Bi-directional electrical characterisation of microbial fuel cell (2013)
Journal Article

The electrical performance of microbial fuel cells in steady-state is usually investigated by standard characterisation methods that reveal many important parameters e.g. maximum power. This paper introduces a novel " bi-directional" method to study... Read More about Bi-directional electrical characterisation of microbial fuel cell.

MFC-cascade stacks maximise COD reduction and avoid voltage reversal under adverse conditions (2013)
Journal Article

Six continuous-flow Microbial Fuel Cells (MFCs) configured as a vertical cascade and tested under different electrical connections are presented. When in parallel, stable operation and higher power and current densities than individual MFCs were obse... Read More about MFC-cascade stacks maximise COD reduction and avoid voltage reversal under adverse conditions.

Maximising electricity production by controlling the biofilm specific growth rate in microbial fuel cells (2012)
Journal Article

The aim of this work is to study the relationship between growth rate and electricity production in perfusion-electrode microbial fuel cells (MFCs), across a wide range of flow rates by co-measurement of electrical output and changes in population nu... Read More about Maximising electricity production by controlling the biofilm specific growth rate in microbial fuel cells.

Effect of mouth-rinse formulations on oral malodour processes in tongue-derived perfusion biofilm model (2012)
Journal Article

An in vitro matrix biofilm perfusion model of tongue-derived microcosms for studying volatile sulfur compound (VSC) biogenesis has been previously described. The model was modified in order to monitor H 2 S in situ by use of a specialized electrode a... Read More about Effect of mouth-rinse formulations on oral malodour processes in tongue-derived perfusion biofilm model.

Comparative effects of various commercially available mouthrinse formulations on oral malodour (2011)
Journal Article

Objectives: The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodour reduction against four commercially available mouthwashes and negative control. A secondary aim was to co... Read More about Comparative effects of various commercially available mouthrinse formulations on oral malodour.

Multivariate analysis of bacterial volatile compound profiles for discrimination between selected species and strains in vitro (2011)
Journal Article

Volatile compounds (VCs) are produced by all microorganisms as part of their normal metabolism. The aim of this study was to determine whether bacterial VC profiles could be used to discriminate between selected bacterial species and strains in vitro... Read More about Multivariate analysis of bacterial volatile compound profiles for discrimination between selected species and strains in vitro.

Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells (2010)
Journal Article

To process large volumes of wastewater, microbial fuel cells (MFCs) would require anodophilic bacteria preferably operating at high flow-rates. The effect of flow-rate on different microbial consortia was examined during anodic biofilm development, u... Read More about Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells.

Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system (2010)
Journal Article

The pH of the tongue biofilm is likely to influence microbial composition and ecology with consequent effects on the metabolic activities and generation of volatile sulfur compounds (VSC) and other malodour gasses. The aim of this study was to identi... Read More about Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system.

Improved energy output levels from small-scale Microbial Fuel Cells (2010)
Journal Article

This study reports on the findings from the investigation into small-scale (6.25mL) MFCs, connected together as a network of multiple units. The MFCs contained unmodified (no catalyst) carbon fibre electrodes and for initial and later experiments, a... Read More about Improved energy output levels from small-scale Microbial Fuel Cells.

Evaluation of the efficacy of electrochemically activated solutions against nosocomial pathogens and bacterial endospores (2010)
Journal Article

Aims: Electrochemically activated solutions (ECAS) are generated from halide salt solutions via specially designed electrolytic cells. The active solutions are known to possess high biocidal activity against a wide range of target microbial species,... Read More about Evaluation of the efficacy of electrochemically activated solutions against nosocomial pathogens and bacterial endospores.

Comparative analysis of different polymer materials for the construction of microbial fuel cell stacks (2010)
Journal Article

A novel in vitro flat-bed perfusion biofilm model for determining the potential antimicrobial efficacy of topical wound treatments (2009)
Journal Article

Aims: To develop an in vitro flat-bed perfusion biofilm model that could be used to determine the antimicrobial efficacy of topically applied treatments. Methods and Results: Pseudomonas aeruginosa and Staphylococcus aureus biofilms were grown within... Read More about A novel in vitro flat-bed perfusion biofilm model for determining the potential antimicrobial efficacy of topical wound treatments.

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