All Outputs (59)

Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer (2022)
Journal Article
Boulind, C. E., Gould, O., Costello, B. D. L., Allison, J., White, P., Ewings, P., …Francis, N. K. (2022). Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer. Cancers, 14(9), 2127. https://doi.org/10.3390/cancers14092127

Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic... Read More about Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer.

Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer (2022)
Journal Article
Lett, L., George, M., Slater, R., De Lacy Costello, B., Ratcliffe, N., García-Fiñana, M., …Probert, C. (2022). Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer. British Journal of Cancer, 127(2), 329-336. https://doi.org/10.1038/s41416-022-01785-8

Background: The diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy. There is a need for biomarkers to reduce the frequency of cystoscopy in surveillance; urinary volatile organic compound (VOC) analysis could fulfil this... Read More about Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer.

Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study (2021)
Journal Article
Drabińska, N., Hewett, K., White, P., Avison, M., Persad, R., Ratcliffe, N., & de Lacy Costello, B. (2021). Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study. Advances in Medical Sciences, 67(1), 1-9. https://doi.org/10.1016/j.advms.2021.09.001

Purpose: Antibiotic resistance is widespread throughout the world and represents a serious health concern. There is an urgent need for the development of novel tools for rapidly distinguishing antibiotic resistant bacteria from susceptible strains. P... Read More about Application of a solid-phase microextraction-gas chromatography-mass spectrometry/metal oxide sensor system for detection of antibiotic susceptibility in urinary tract infection-causing Escherichia coli – A proof of principle study.

Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs) (2020)
Journal Article
Fois, M., Cox, T., Ratcliffe, N., & de Lacy Costello, B. (2021). Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs). Sensors and Actuators B: Chemical, 330, Article 129264. https://doi.org/10.1016/j.snb.2020.129264

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties whe... Read More about Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs).

Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study (2020)
Journal Article
Hewett, K., Drabinska, N., White, P., Avison, M., Persad, R., Ratcliffe, N., & de Lacy Costello, B. (2020). Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study. Antibiotics, 9(11), 797. https://doi.org/10.3390/antibiotics9110797

Antibiotic resistance is an unprecedented threat to modern medicine. The analysis of volatile organic compounds (VOCs) from bacteria potentially offers a rapid way to determine antibiotic susceptibility in bacteria. This study aimed to find the optim... Read More about Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study.

Neuromorphic liquid marbles with aqueous carbon nanotube cores (2019)
Journal Article
Mayne, R., Draper, T. C., Phillips, N., Whiting, J. G. H., Weerasekera, R., Fullarton, C., …Adamatzky, A. (2019). Neuromorphic liquid marbles with aqueous carbon nanotube cores. Langmuir, 35, 13182-13188. https://doi.org/10.1021/acs.langmuir.9b02552

Neuromorphic computing devices attempt to emulate features of biological nervous systems through mimicking the properties of synapses, towards implementing the emergent properties of their counterparts, such as learning. Inspired by recent advances i... Read More about Neuromorphic liquid marbles with aqueous carbon nanotube cores.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article
Smart, A., de Lacy Costello, B., White, P., Avison, M., Batty, C., Turner, C., …Ratcliffe, N. (2019). Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles. Journal of Pharmaceutical and Biomedical Analysis, 167, 59-65. https://doi.org/10.1016/j.jpba.2019.01.044

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds (2018)
Journal Article
Gould, O., Costello, B. D. L., Smart, A., Jones, P., Macmaster, A., Ransley, K., & Ratcliffe, N. (2018). Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds. Metabolites, 8(4), 75. https://doi.org/10.3390/metabo8040075

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. It has become increasingly important to qualitatively and quantitatively assess the volatile metabolites in a range of bodily fluids for use in monitoring health. There has been relatively lit... Read More about Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds.

Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds (2017)
Journal Article
Gould, O., Ratcliffe, N. M., De Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds. Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

© 2017 IOP Publishing Ltd. There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications... Read More about Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds.

Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis (2016)
Journal Article
Aggio, R. B., White, P., Jayasena, H., de Lacy Costello, B., Ratcliffe, N. M., & Probert, C. S. (2017). Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis. Alimentary Pharmacology and Therapeutics, 45(1), 82-90. https://doi.org/10.1111/apt.13822

© 2016 John Wiley & Sons Ltd Background: Inflammatory bowel disease and irritable bowel syndrome may present in a similar manner. Measuring faecal calprotectin concentration is often recommended to rule out inflammatory bowel disease, however, ther... Read More about Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis.

Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection (2014)
Journal Article
Vaughan, K., Probert, C. S., Garner, C. E., McGuire, N. D., Ewen, R. J., de Lacy Costello, B., & Ratcliffe, N. M. (2014). Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection. Measurement Science and Technology, 25(6), https://doi.org/10.1088/0957-0233/25/6/065108

Rapid volatile profiling of stool sample headspace was achieved using a combination of short multi-capillary chromatography column (SMCC), highly sensitive heated metal oxide semiconductor sensor and artificial neural network software. For direct ana... Read More about Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection.

The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients (2014)
Journal Article
Vaughan, K., Shepherd, S. F., McGuire, N. D., de Lacy Costello, B., Ewen, R. J., Jayasena, D. H., …Ratcliffe, N. M. (2014). The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients. Journal of Breath Research, 8(2), https://doi.org/10.1088/1752-7155/8/2/026001

There is much clinical interest in the development of a low-cost and reliable test for diagnosing inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), two very distinct diseases that can present with similar symptoms. The assessment o... Read More about The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients.

An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS (2013)
Journal Article
Ratcliffe, N., De Lacy Costello, B., Al-Kateb, H., de Lacy Costello, B., & Ratcliffe, N. M. (2013). An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS. Journal of Breath Research, 7(3), https://doi.org/10.1088/1752-7155/7/3/036004

Analysis of volatile organic compounds (VOCs) from saliva, to aid disease diagnoses, has received little attention. This work aims to address the paucity of information on saliva volatiles and includes a database of newly identified compounds whilst... Read More about An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS.

A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace (2013)
Journal Article
Ratcliffe, N., Probert, C. S., Ewen, R., Khalid, T., White, P., De Lacy Costello, B., …Ratcliffe, N. M. (2013). A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace. PLoS ONE, 8(7), https://doi.org/10.1371/journal.pone.0069602

There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers to screen for bladder cancer. In this paper, we evaluate a new simple in-house fabricated, GC-sensor device in the diagnosis... Read More about A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace.

Observation, characterization and modeling of memristor current spikes (2013)
Journal Article
Gale, E., de Lacy Costello, B., & Adamatzky, A. (2013). Observation, characterization and modeling of memristor current spikes. https://doi.org/10.12785/amis/070418

Memristors have been compared to neurons (usually specifically the synapses) since 1976 but no experimental evidence has been offered for support for this position. Here we highlight that memristors naturally form fast-response, highly reproducible a... Read More about Observation, characterization and modeling of memristor current spikes.

The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease (2013)
Journal Article
Ratcliffe, N. M., de Lacy Costello, B., & Shepherd, S. (2013). The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease. Clinical laboratory international, 37, 18-20

Currently, the diagnosis of bowel diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) relies on invasive and expensive procedures. Identification of biomarker-based tests to aid diagnosis is an important area of resea... Read More about The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease.

An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome (2013)
Journal Article
Probert, C. S., de Costello, B. L., Ahmed, I., Greenwood, R., de Lacy Costello, B., Ratcliffe, N. M., & Probert, C. (2013). An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome. PLoS ONE, 8(3), https://doi.org/10.1371/journal.pone.0058204

Diagnosing irritable bowel syndrome (IBS) can be a challenge; many clinicians resort to invasive investigations in order to rule out other diseases and reassure their patients. Volatile organic metabolites (VOMs) are emitted from feces; understanding... Read More about An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome.

Volatiles from oral anaerobes confounding breath biomarker discovery (2013)
Journal Article
De Lacy Costello, B., Khalid, T. Y., Ratcliffe, N. M., Khalid, T., Saad, S., Greenman, J., …Ratcliffe, N. M. (2013). Volatiles from oral anaerobes confounding breath biomarker discovery. Journal of Breath Research, 7(1), https://doi.org/10.1088/1752-7155/7/1/017114

The levels of compounds in exhaled mouth air do not necessarily reflect levels in the systemic circulation as bacteria can bio-transform substrates to produce compounds within the mouth. This should be of concern to researchers measuring breath volat... Read More about Volatiles from oral anaerobes confounding breath biomarker discovery.

Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks (2011)
Journal Article
Holley, J., Jahan, I., De Lacy Costello, B., Bull, L., & Adamatzky, A. (2011). Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks. Physical Review E, 84(5), 056110. https://doi.org/10.1103/PhysRevE.84.056110

Excitation waves on a subexcitable Belousov-Zhabotinsky (BZ) substrate can be manipulated by chemical variations in the substrate and by interactions with other waves. Symbolic assignment and interpretation of wave dynamics can be used to perform log... Read More about Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks.

Towards constructing one-bit binary adder in excitable chemical medium (2011)
Journal Article
de Lacy Costello, B., Adamatzky, A., Jahan, I., & Zhang, L. (2011). Towards constructing one-bit binary adder in excitable chemical medium. Chemical Physics, 381(1-3), 88-99. https://doi.org/10.1016/j.chemphys.2011.01.014

The light-sensitive modification (ruthenium catalysed) of the Belousov-Zhabotinsky reaction exhibits various excitability regimes depending on the level of illumination. Within a narrow range of applied illumination levels the medium is in a sub-exci... Read More about Towards constructing one-bit binary adder in excitable chemical medium.