Adherence therapy for medication non-compliant patients with hypertension: A randomised controlled trial

Deane, K. H. O.; Alhalaiqa, F.; Nawafleh, A. H.; Gray, Richard; Clark, A.

Abstract

The objective of this study is to establish the efficacy of adherence therapy (AT) compared with treatment as usual (TAU) in reducing blood pressure (BP) in non-compliant hypertensive patients. This study was designed as a parallel-group single-blind randomised controlled trial. The study was carried out at three general hospital outpatient clinics in Jordan. A total of 136 non-compliant hypertensive patients with a mean baseline BP of 164.5 mm Hg (s.d. 10.0) over 102.2 mm Hg (s.d. 7.0) participated in the study. 7 weekly 20-min sessions of AT in addition to TAU. The main outcome of this study is systolic blood pressure (SBP) at 11-weeks follow-up. In all, 68 patients received TAU and 68 AT. Intention-to-treat analysis included all participants randomised. AT lowered SBP by 23.11 mm Hg (95% CI: 25.85, 20.36) and diastolic BP (DBP) by 15.18 mm Hg (95% CI: 17.55, 12.80) at 11 weeks compared with TAU. Adherence (measured by pill counting) was also improved in the AT group by 37% at 11 weeks compared with TAU. No significant adverse events were reported. AT increases adherence to medication for hypertension which then leads to a clinically important reduction in BP. © 2012 Macmillan Publishers Limited All rights reserved.

• Journal Article Type: Article
• Publication Date: Feb 1, 2012
• Journal: Journal of Human Hypertension
• Print ISSN: 0950-9240
• Electronic ISSN: 1476-5527
• Publisher: Springer Nature [academic journals on nature.com]
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 2
• Pages: 117-126
• DOI: https://doi.org/10.1038/jhh.2010.133
• Keywords: randomised controlled trial, adherence, therapy, compliance, beliefs about medication
• Public URL: https://uwe-repository.worktribe.com/output/965239
• Publisher URL: http://dx.doi.org/10.1038/jhh.2010.133