Lawrence Bull Larry.Bull@uwe.ac.uk
School Director (Research & Enterprise) and Professor
A simple computational cell: Coupling boolean gene and protein networks
Bull, Larry
Authors
Abstract
This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2012 |
Journal | Artificial Life |
Print ISSN | 1064-5462 |
Electronic ISSN | 1530-9185 |
Publisher | Massachusetts Institute of Technology Press (MIT Press) |
Peer Reviewed | Peer Reviewed |
Volume | 18 |
Issue | 2 |
Pages | 223-236 |
Keywords | protein interaction networks, automata, biology, model, regulatory networks |
Public URL | https://uwe-repository.worktribe.com/output/952002 |
Publisher URL | http://mitpress.mit.edu |
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