A simple computational cell: Coupling boolean gene and protein networks

Bull, Larry

Abstract

This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.

• Journal Article Type: Article
• Publication Date: Jan 1, 2012
• Journal: Artificial Life
• Print ISSN: 1064-5462
• Electronic ISSN: 1530-9185
• Publisher: Massachusetts Institute of Technology Press (MIT Press)
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 2
• Pages: 223-236
• Keywords: protein interaction networks, automata, biology, model, regulatory networks
• Public URL: https://uwe-repository.worktribe.com/output/952002
• Publisher URL: http://mitpress.mit.edu