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A simple computational cell: Coupling boolean gene and protein networks

Bull, Larry

Authors

Lawrence Bull Larry.Bull@uwe.ac.uk
School Director (Research & Enterprise) and Professor



Abstract

This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.

Journal Article Type Article
Publication Date Jan 1, 2012
Journal Artificial Life
Print ISSN 1064-5462
Electronic ISSN 1530-9185
Publisher Massachusetts Institute of Technology Press (MIT Press)
Peer Reviewed Peer Reviewed
Volume 18
Issue 2
Pages 223-236
Keywords protein interaction networks, automata, biology, model, regulatory networks
Public URL https://uwe-repository.worktribe.com/output/952002
Publisher URL http://mitpress.mit.edu