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The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells

Adamo, Patricia; Porazinski, Sean; Rajatileka, Shavanthi; Jumbe, Samantha; Hagen, Rachel; Wilson, Ian D; Cheung, Man Kim; Ladomery, Michael

Authors

Patricia Adamo

Sean Porazinski Sean.Porazinski@uwe.ac.uk

Shavanthi Rajatileka

Samantha Jumbe Samantha.Jumbe@uwe.ac.uk

Rachel Hagen

Man Kim Cheung Man-kim.Cheung@uwe.ac.uk



Abstract

© 2017, Spandidos Publications. All rights reserved. The oncogene ETS-related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. The ERG oncogene is activated in >50% of prostate cancer cases, generally through a gene fusion with the androgen-responsive promoter of transmembrane protease serine 2. Phosphatase and tensin homologue (PTEN) is an important tumour suppressor gene that is often inactivated in cancer. ERG overexpression combined with PTEN inactivation or loss is often associated with aggressive prostate cancer. The present study aimed to determine whether or not ERG regulates PTEN transcription directly. ERG was demonstrated to bind to the PTEN promoter and repress its transcription. ERG overexpression reduced endogenous PTEN expression, whereas ERG knockdown increased PTEN expression. The ability of ERG to repress PTEN may contribute to a more cancer-permissive environment.

Citation

Ladomery, M. R., Wilson, I., Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., …Ladomery, M. (2017). The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncology Letters, 14(5), 5605-5610. https://doi.org/10.3892/ol.2017.6841

Journal Article Type Article
Acceptance Date Jul 1, 2017
Online Publication Date Aug 28, 2017
Publication Date Nov 1, 2017
Journal Oncology Letters
Print ISSN 1792-1074
Electronic ISSN 1792-1082
Publisher Spandidos Publications
Peer Reviewed Peer Reviewed
Volume 14
Issue 5
Pages 5605-5610
DOI https://doi.org/10.3892/ol.2017.6841
Keywords oncogenic transcription factor, ERG, tumour suppressor gene, PTEN, prostate cancer, cells
Public URL https://uwe-repository.worktribe.com/output/884655
Publisher URL https://doi.org/10.3892/ol.2017.6841

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