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Immunotherapeutic and pharmacological approaches for the treatment of Alzheimer’s disease

Usmari Moraes, Marcela; Gaudet, Timothy; Hull, Jonathon; Conway, Myra E

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Authors

Marcela Usmari Moraes

Timothy Gaudet

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Jonathon Hull Jonathon2.Hull@uwe.ac.uk
Senior Lecturer in Biomedical Sci (Biochemistry)

Myra Conway Myra.Conway@uwe.ac.uk
Occasional Associate Lecturer - CHSS - DAS



Abstract

The development of efficacious treatments targeting Alzheimer’s disease (AD) aetiology has been proved an extensive, time consuming task. Currently prescribed therapies, primarily acetylcholinesterase inhibitors such as donepezil and the NMDAreceptor antagonist memantine, concentrate on the improvement of symptoms such as cognitive decline and memory loss, however, do not address the underlying pathology of the condition. More recently, efforts have focused on developing drugs that target the hallmarks of AD, amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Many clinical trials focusing on the removal of these proteins are presently ongoing, primarily exploring immunotherapeutic avenues such as the antibody aducanumab (targeting Aβ) and the vaccine AADvac-1 (targeting tau). However, the incomplete understanding of AD progression presents a challenge, and further studies focusing on the development of the disease are essential to the expansion of novel, efficient therapeutic routes.

Journal Article Type Article
Acceptance Date Feb 13, 2018
Online Publication Date Apr 12, 2018
Publication Date Jul 1, 2018
Deposit Date Jul 9, 2018
Publicly Available Date Jul 9, 2018
Journal Bioscience Horizons: The International Journal of Student Research
Print ISSN 1754-7431
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 11
Pages 1-7
Keywords amyloid, antibody, dementia, immunotherapy, tau, therapeutics
Public URL https://uwe-repository.worktribe.com/output/865145
Publisher URL https://doi.org/10.1093/biohorizons/hzy001
Contract Date Jul 9, 2018

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