Which intravenous bronchodilators are being administered to children presenting with acute severe wheeze in the UK and Ireland?

Powell, Collin V.E.; Lyttle, M. D.; Morris, I.; Lyttle, Mark; O'Sullivan, R.; Sargant, N.; Doull, I. J.M.; Powell, C.V.E.

Abstract

During a prospective 10-week assessment period, 3238 children aged 1-16 years presented with acute wheeze to Paediatric Emergency Research in the UK and Ireland centres. 110 (3.3%) received intravenous bronchodilators. Intravenous magnesium sulfate (MgSO4) was used in 67 (60.9%), salbutamol in 61 (55.5%) and aminophylline in 52 (47.3%) of cases. In 35 cases (31.8%), two drugs were used together, and in 18 cases (16.4%), all three drugs were administered. When used sequentially the most common order was salbutamol, then MgSO4, then aminophylline. Overall, 30 different intravenous treatment regimens were used varying in drugs, dose, rate and duration.

• Journal Article Type: Article
• Publication Date: Jan 1, 2015
• Publicly Available Date: Jun 6, 2019
• Journal: Thorax
• Print ISSN: 0040-6376
• Electronic ISSN: 1468-3296
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 70
• Issue: 1
• Pages: 88-91
• DOI: https://doi.org/10.1136/thoraxjnl-2014-206041
• Keywords: intravenous bronchodilators, children, acute severe wheeze, UK, Ireland
• Public URL: https://uwe-repository.worktribe.com/output/840258
• Publisher URL: http://dx.doi.org/10.1136/thoraxjnl-2014-206041
• Additional Information: Additional Information : Published Online First: 10 October 2014