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Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom

Marlow, Robin; Muir, P.; Vipond, B.; Lyttle, Mark; Trotter, C.; Finn, A.

Authors

Robin Marlow

P. Muir

B. Vipond

Mark Lyttle mark.lyttle@uwe.ac.uk

C. Trotter

A. Finn



Abstract

© 2015, European Centre for Disease Prevention and Control (ECDC). All rights reserved. The United Kingdom (UK) added rotavirus (RV) vaccine (Rotarix GlaxoSmithKline) to the national vaccine schedule in July 2013. During the 2012–2014 rotavirus seasons, children presenting to the Bristol Royal Hospital for Children Emergency Department with gastroenteritis symptoms had stool virology analysis (real-time PCR) and clinical outcome recorded. Nosocomial cases were identified as patients with non-gastroenteritis diagnosis testing positive for rotavirus > 48h after admission. In comparison to average pre-vaccine seasons, in the first year after vaccine introduction there were 48% fewer attendances diagnosed with gastroenteritis, 53% reduction in gastroenteritis admissions and a total saving of 330 bed-days occupancy. There was an overall reduction in number of rotavirus-positive stool samples with 94% reduction in children aged under one year and a 65% reduction in those too old to have been vaccinated. In the first year after the introduction of universal vaccination against rotavirus we observed a profound reduction in gastroenteritis presentations and admissions with a substantial possible herd effect seen in older children. Extrapolating these findings to the UK population we estimate secondary healthcare savings in the first year of ca £7.5 (€10.5) million. Ongoing surveillance will be required to determine the long-term impact of the RV immunisation programme.

Journal Article Type Article
Publication Date Dec 3, 2015
Journal Eurosurveillance
Print ISSN 1560-7917
Electronic ISSN 1560-7917
Publisher European Centre for Disease Prevention and Control
Peer Reviewed Peer Reviewed
Volume 20
Issue 48
Institution Citation Lyttle, M., Marlow, R., Muir, P., Vipond, B., Lyttle, M., Trotter, C., & Finn, A. (2015). Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom. Eurosurveillance, 20(48), https://doi.org/10.2807...917.ES.2015.20.48.30077
DOI https://doi.org/10.2807/1560-7917.ES.2015.20.48.30077
Keywords rotavirus, vaccine, children
Publisher URL http://www.eurosurveillance.org/images/dynamic/EE/V20N48/V20N48.pdf