Risk of traumatic intracranial haemorrhage in children with bleeding disorders

Bressan, Silvia; Monagle, Paul; Dalziel, Stuart R.; Borland, Meredith L.; Phillips, Natalie; Kochar, Amit; Lyttle, Mark D.; Cheek, John A.; Neutze, Jocelyn; Oakley, Ed; Dalton, Sarah; Gilhotra, Yuri; Hearps, Stephen; Furyk, Jeremy; Babl, Franz E.; Paediatric Research in Emergency Departments International Collaborative (PREDICT)

Abstract

Objective: To assess computerized tomography (CT) use and the risk of intracranial haemorrhage (ICH) in children with bleeding disorders following a head trauma
Design: Multicentre prospective observational study
Setting: 10 paediatric emergency departments (ED) in Australia and New Zealand
Patients: Children < 18 years with and without bleeding disorders assessed in ED following head trauma between April 2011 and November 2014
Interventions: Data collection of patient characteristics, management and outcomes
Main outcome measures: Rate of CT use and frequency of ICH on CT
Results: Of 20,137 patients overall, 103 (0.5%) had a congenital or acquired bleeding disorder. CT use was higher in these patients compared with children without bleeding disorders (30.1% vs 10.4%; rate ratio 2.91 95%CI 2.16- 3.91). Only one of 31 (3.2%) children who underwent CT in the ED had an ICH. This patient rapidly deteriorated in the ED on arrival and required neurosurgery. None of the patients with bleeding disorders who did not have a CT obtained in the ED or had an initial negative CT had evidence of ICH on follow up.
Conclusions: Although children with a bleeding disorder and a head trauma more often receive a CT scan in the ED, their risk of ICH seems low and appears associated with post-traumatic clinical findings. Selective CT use combined with observation may be cautiously considered in these children based on clinical presentation and severity of bleeding disorder.

Citation

Bressan, S., Monagle, P., Dalziel, S. R., Borland, M. L., Phillips, N., Kochar, A., …Paediatric Research in Emergency Departments International Collaborative (PREDICT). (2020). Risk of traumatic intracranial haemorrhage in children with bleeding disorders. Journal of Paediatrics and Child Health, 56(12), 1891-1897. https://doi.org/10.1111/jpc.15073

• Journal Article Type: Article
• Acceptance Date: Jun 18, 2020
• Online Publication Date: Aug 18, 2020
• Publication Date: Dec 1, 2020
• Deposit Date: Sep 1, 2020
• Publicly Available Date: Aug 19, 2021
• Journal: Journal of Paediatrics and Child Health
• Print ISSN: 1034-4810
• Electronic ISSN: 1440-1754
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 12
• Pages: 1891-1897
• DOI: https://doi.org/10.1111/jpc.15073
• Keywords: Pediatrics, Perinatology, and Child Health
• Public URL: https://uwe-repository.worktribe.com/output/6641917