Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles

Smith, Andrew; Tilling, Kate; Lawlor, Debbie A.; Nelson, Scott M.

Abstract

BACKGROUND: It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred. METHODS: In a prospective study of UK Human Fertilisation and Embryology Authority data, we investigated the impact of segmentation, compared with initial fresh embryo followed by frozen embryo transfers, on live birth rate and perinatal outcomes. We used generalised linear models to assess the effect of segmentation in the whole cohort, with additional analyses within women who had experienced both segmentation and non-segmentation. We compared rates of live birth, low birthweight (LBW

• Journal Article Type: Article
• Acceptance Date: Sep 19, 2019
• Online Publication Date: Nov 13, 2019
• Publication Date: Nov 13, 2019
• Deposit Date: Sep 30, 2019
• Publicly Available Date: Nov 26, 2019
• Journal: BMC medicine
• Electronic ISSN: 1741-7015
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 1
• Article Number: 202
• DOI: https://doi.org/10.1186/s12916-019-1429-z
• Keywords: IVF, freeze-all, perinatal outcome, frozen embryo transfer
• Public URL: https://uwe-repository.worktribe.com/output/3391786