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The effects of omeprazole on the neuron-like spiking of the electrical potential of proteinoid microspheres

Mougkogiannis, Panagiotis; Adamatzky, Andrew

The effects of omeprazole on the neuron-like spiking of the electrical potential of proteinoid microspheres Thumbnail


Authors

Panagiotis Mougkogiannis



Abstract

This study examines a new approach to hybrid neuromorphic devices by studying the impact of omeprazole–proteinoid complexes on Izhikevich neuron models. We investigate the influence of these metabolic structures on five specific patterns of neuronal firing: accommodation, chattering, triggered spiking, phasic spiking, and tonic spiking. By combining omeprazole, a proton pump inhibitor, with proteinoids, we create a unique substrate that interfaces with neuromorphic models. The Izhikevich neuron model is used because it is computationally efficient and can accurately simulate the various behaviours of cortical neurons. The results of our simulations show that omeprazole–proteinoid complexes have the ability to affect neuronal dynamics in different ways. This suggests that they could be used as adjustable components in bio-inspired computer systems. We noticed a notable alteration in the frequency of spikes, patterns of bursts, and rates of adaptation, especially in chattering and triggered spiking behaviours. The findings indicate that omeprazole–proteinoid complexes have the potential to serve as adaptable elements in neuromorphic systems, presenting novel opportunities for information processing and computation that have origins in neurobiological principles. This study makes a valuable contribution to the expanding field of biochemical neuromorphic devices and establishes a basis for the development of hybrid bio-synthetic computational systems.

Journal Article Type Article
Acceptance Date Oct 2, 2024
Online Publication Date Oct 4, 2024
Publication Date 2024-10
Deposit Date Oct 4, 2024
Publicly Available Date Oct 4, 2024
Electronic ISSN 1420-3049
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 29
Issue 19
Article Number 4700
DOI https://doi.org/10.3390/molecules29194700
Public URL https://uwe-repository.worktribe.com/output/13265984

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