Proto-neurons from abiotic polypeptides

Mougkogiannis, Panagiotis; Adamatzky, Andrew

Abstract

To understand the origins of life, we must first gain a grasp of the unresolved emergence of the first informational polymers and cell-like assemblies that developed into living systems. Heating amino acid mixtures to their boiling point produces thermal proteins that self-assemble into membrane-bound protocells, offering a compelling abiogenic route for forming polypeptides. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. This review examines the characteristics exhibited by proteinoids, including electrical activity and self-assembly properties, exploring the possible roles of such polypeptides under prebiotic conditions in the emergence of early biomolecular complexity. Experiments showcasing the possibility of unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.

Citation

Mougkogiannis, P., & Adamatzky, A. (2024). Proto-neurons from abiotic polypeptides. Encyclopedia, 4(1), 512-543. https://doi.org/10.3390/encyclopedia4010034

• Journal Article Type: Article
• Acceptance Date: Mar 4, 2024
• Online Publication Date: Mar 8, 2024
• Publication Date: Mar 8, 2024
• Deposit Date: Mar 8, 2024
• Publicly Available Date: Mar 12, 2024
• Journal: Encyclopedia
• Print ISSN: 2673-8392
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 1
• Pages: 512-543
• DOI: https://doi.org/10.3390/encyclopedia4010034
• Keywords: proteinoids; origin of life; proteins
• Public URL: https://uwe-repository.worktribe.com/output/11769181