Olena Doran Olena.Doran@uwe.ac.uk
College Dean of Research and Enterprise
Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats
Doran (nee Udovikova), Olena; Lemeshko, V. V.
Authors
V. V. Lemeshko
Abstract
The subject under investigation is the influence of osmotic pressure of incubation medium (25-500 mM of sucrose) upon the respiration and the respiration control (RC) of mitochondria of the liver of rats aged 1, 3, 12 and 24 months when oxidizing succinate. In a medium with 0.3 M of sucrose the respiration rate under condition 3 (V3) and RC increased from the age of 1 to 12 months and decreased by 24 months. In a medium with 0.15 M of sucrose the age differences have not been observed. In a uncoupling state the osmotic dependence of the respiration of mitochondria of 1- and 12-month-old rats did not vary. It is assumed that with age there is a change in the rate of structural coupling of the carrier of adenine nucleotides with H(+)-ATP synthetase complex and (or) the viscosity of the matrix.
| Journal Article Type | Article |
|---|---|
| Publication Date | Feb 1, 1991 |
| Journal | Biulleten Eksperimental'noi Biologii i Mediciny |
| Peer Reviewed | Peer Reviewed |
| Volume | 111 |
| Issue | 2 |
| Pages | 150-152 |
| Keywords | mitochondria, aging |
| Public URL | https://uwe-repository.worktribe.com/output/1110474 |
| Publisher URL | http://www.ncbi.nlm.nih.gov/pubmed/1854956 |
| Additional Information | Additional Information : Article in Russian, abstract in English Corporate Creators : Kharkiv State University, Ukraine |