Physical activity, kidney function, physical function, and health-related quality of life in adults with non-dialysis chronic kidney disease

Niyi-Odumosu, Faatihah

Abstract

This thesis aimed to report the development of evidence-based studies that would assess current physical activity and function, health related quality of life and association with kidney function to encourage and facilitate sustained physical activity habits amongst patients with non-dialysis chronic kidney disease (CKD) and their health care professionals. Therefore, the following studies were conducted:
A cross-sectional study of associations of kidney function with self-reported physical activity, physical function, and health-related quality of life (HRQoL): We demonstrated low distribution of Health Enhancing Physically Active (HEPA) (26%) amongst 70 patients with stages 1-5 CKD, with associations between kidney function vs physical activity and physical function after adjusting for confounding variables, but not with HRQoL.
A cross-sectional study of self-reported physical activity, physical function, HRQoL, readiness and confidence to increase physical activity: This multi-centre study amongst 377 patients with stages 3-5 CKD indicated a low distribution of active patients (5%) and low levels of confidence and readiness to increase activity. Regression models suggested physical activity, physical function, and physical health are independent positive predictors of readiness and confidence to increase physical activity.
An observational study of associations of physical activity, diet, inflammatory markers, and kidney function in non-diabetic hyperglycaemic adults with early stage CKD: This study assessed baseline and 12 months follow up data of 159 adults at high risk of T2DM in stage 2 CKD recruited to a lifestyle structured education programme. With regression models, there were no associations between kidney function and objective measures of physical activity, dietary fats and fibre and C-reactive protein.
A cross-sectional study of physical activity as a therapeutic option for patients living with CKD in Nigeria: The Renal Multidisciplinary Team Perspective: This survey-based study of 281 renal health care professionals in Nigeria indicated a high prevalence of insufficient physical activity (74%). There were positive opinions and attitudes about implementing physical activity in the care of patients, but with a low distribution of those that implement it (11%). The reported barriers that could have accounted for this inadequacy were lack of motivated patients due to ill health and lack of awareness (75%), lack of resources (69%) and funds (66%), and lack of motivated staff (63%).
Conclusion: The studies reported in this thesis demonstrated associations between kidney function, physical activity, physical function and health-related quality of life. It further demonstrated low levels of physical activity and low levels of confidence and readiness to increase physical activity. Furthermore, both patients and health care professionals had positive attitudes towards the benefits of physical activity, but implementation rates were low. Therefore, there is an urgent need to explore effective methods to promote and facilitate physical activity amongst patients with stages 1-5 non-dialysis CKD and their health care professionals.

• Thesis Type: Thesis
• Deposit Date: Jun 17, 2023
• Public URL: https://uwe-repository.worktribe.com/output/10870953
• Award Date: Jun 4, 2019