Outputs (7)

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation (2021)
Journal Article

Background: Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly understood. We aim to investigate the vaginal microbial composition and the local immu... Read More about Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation.

Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration (2021)
Journal Article

Background: Pregnant women living with HIV infection (PWLWH) have elevated rates of preterm birth (PTB) in which HIV and cART are implicated. PWLWH also have a high prevalence of adverse vaginal microbiota, which associate with genital tract inflamma... Read More about Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration.

The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia (2021)
Journal Article

Background: Vaginal microbiota (VMB) composition is altered in women with cervical intra-epithelial neoplasia (CIN) compared to healthy controls and is associated with disease progression. However, the impact of CIN excision on the VMB and innate imm... Read More about The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia.

Telomere length in cystic fibrosis patients – Are patients with CF ageing too quickly? (2021)
Journal Article

Life expectancy for patients living with Cystic Fibrosis (CF) is increasing year on year and there is growing interest in the ageing process in CF. Telomeres are repetitive sequences of DNA that cap the ends of eukaryotic chromosomes and shorten with... Read More about Telomere length in cystic fibrosis patients – Are patients with CF ageing too quickly?.

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth (2021)
Journal Article

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)... Read More about Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth.

O-129 Lactobacillus deplete vaginal microbial composition is associated with chromosomally normal miscarriage and local inflammation (2021)
Journal Article

Study question
To investigate the vaginal microbial composition and the local immune response in chromosomally normal and abnormal miscarriages and compare this to uncomplicated pregnancies delivering at term.

Summary answer
We show that euploid... Read More about O-129 Lactobacillus deplete vaginal microbial composition is associated with chromosomally normal miscarriage and local inflammation.

The association between obesity and weight loss after bariatric surgery on the vaginal microbiota (2021)
Journal Article

Background: Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammat... Read More about The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.