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Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration

Short, Charlotte-Eve S; Quinlan, Rachael A; Wang, Xuan; Preda, Veronica Georgiana; Smith, Ann; Marchesi, Julian R; Lee, Yooni S; Macintyre, David A; Bennett, Phillip R; Taylor, Graham P

Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration Thumbnail


Authors

Charlotte-Eve S Short

Rachael A Quinlan

Xuan Wang

Veronica Georgiana Preda

Ann Smith

Julian R Marchesi

Yooni S Lee

David A Macintyre

Phillip R Bennett

Graham P Taylor



Abstract

Background: Pregnant women living with HIV infection (PWLWH) have elevated rates of preterm birth (PTB) in which HIV and cART are implicated. PWLWH also have a high prevalence of adverse vaginal microbiota, which associate with genital tract inflammation. The mechanism underlying PTB in PWLWH is unknown. We present the first data in PWLWH on genital-tract matrix-metalloproteinase-9(MMP-9), an important collagenase implicated in labour onset, and tissue inhibitor of metalloproteinases-1(TIMP-1) and explore correlations with local inflammation and vaginal bacteria.

Journal Article Type Article
Acceptance Date Nov 3, 2021
Online Publication Date Nov 29, 2021
Publication Date Nov 29, 2021
Deposit Date Dec 14, 2021
Publicly Available Date Dec 17, 2021
Journal Frontiers in Cellular and Infection Microbiology
Electronic ISSN 2235-2988
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 750103
DOI https://doi.org/10.3389/fcimb.2021.750103
Public URL https://uwe-repository.worktribe.com/output/8185920

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Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration (5.4 Mb)
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Licence
http://creativecommons.org/licenses/by/4.0/

Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Under the CC-BY 4.0 license this is the published version of the following article: Short, C. S., Quinlan, R. A., Wang, X., Preda, V. G., Smith, A., Marchesi, J. R., …Taylor, G. P. (2021). Vaginal Microbiota, Genital Inflammation and Extracellular Matrix Remodelling Collagenase: MMP-9 in Pregnant Women With HIV, a Potential Preterm Birth Mechanism Warranting Further Exploration. Frontiers in Cellular and Infection Microbiology, 11, https://doi.org/10.3389/fcimb.2021.750103, which has been published in final form at https://doi.org/10.3389/fcimb.2021.750103.





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