Outputs (2)

Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity (2010)
Journal Article

G-protein coupled receptors (GPCRs) form a crucial component of approximately 80% of hormone pathways. In this paper, the most popular mechanism for activation of GPCRs-the shuttling mechanism-is modelled mathematically. An asymptotic analysis of thi... Read More about Modelling of the activation of G-protein coupled receptors: Drug free constitutive receptor activity.

Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: Agonist-antagonist competition (2010)
Journal Article

A new mathematical model of cell signalling for a two-ligand G-protein coupled receptor (GPCR) system is presented. This model extends the single-ligand cubic ternary complex to account for the possibility of an agonist and an antagonist competing fo... Read More about Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: Agonist-antagonist competition.