Outputs (10)

The PTEN conundrum: How to target PTEN-deficient prostate cancer (2020)
Journal Article

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to advanced prostate cancer progression and poor clinical outcome. Accordingly, se... Read More about The PTEN conundrum: How to target PTEN-deficient prostate cancer.

Biodistribution PET/CT study of Hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice (2020)
Journal Article

Proteins, as a major component of organisms, are considered the preferred biomaterials for drug delivery vehicles. Hemoglobin (Hb) has been recently rediscovered as a potential drug carrier, but its use for biomedical applications still lacks extensi... Read More about Biodistribution PET/CT study of Hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice.

Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning (2020)
Journal Article

Haemolytic anaemias arise when red blood cell (RBC) integrity is compromised, eventually resulting in premature clearance or lysis and leading to anaemia when these effects cannot be sufficiently compensated by the capacity of the bone marrow to prod... Read More about Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning.

Nanoparticle-based 3D membrane for impedimetric biosensor applications (2020)
Journal Article

This paper reports on a comparison between nano-ZnO/CuO and nano-ZnO nitrocellulose membrane biosensors, both of which were fabricated using a simple and inexpensive sonication technique. To produce the nano-ZnO/CuO membranes, the technique involved... Read More about Nanoparticle-based 3D membrane for impedimetric biosensor applications.

The metabolic profiles and bacterial interactions of Bacteroides fragilis, Salmonella enterica serovar Typhimurium, E. coli Nissle 1917 and Clostridium perfringens on RG/C2 (benign) and HCT116 (malignant) colorectal tumour cell lines (2020)
Presentation / Conference Contribution

The aim of this research was to determine the interaction of the afore mentioned bacterial species on the attachment and invasion of both benign and malignant tumour cells using the gentamicin and metronidazole bacterial infection assay. The results... Read More about The metabolic profiles and bacterial interactions of Bacteroides fragilis, Salmonella enterica serovar Typhimurium, E. coli Nissle 1917 and Clostridium perfringens on RG/C2 (benign) and HCT116 (malignant) colorectal tumour cell lines.

Allium cepa remediates oxidative stress-mediated hepatic DNA damage in cadmium-exposed rats through enhanced p53 expression and inhibition of bcl2 (2020)
Journal Article

BACKGROUND:
Cadmium (Cd), a naturally occurring toxic metal, in addition to being cytotoxic, has been shown to be responsible for inducing free radical-dependent DNA damage in cells. Allium cepa is also known to ameliorate cadmium sulphate-induced... Read More about Allium cepa remediates oxidative stress-mediated hepatic DNA damage in cadmium-exposed rats through enhanced p53 expression and inhibition of bcl2.

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis (2020)
Journal Article

Dehydrated hereditary stomatocytosis 1 or hereditary xerocytosis (HX, OMIM 194380) is a rare hereditary autosomal dominant disorder characterized by hemolytic anemia and red blood cell (RBC) dehydration. The occurrence of HX is linked with gain-of-fu... Read More about PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis.

Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation (2020)
Journal Article

The effects of ionising radiation (IR) on plants are important for environmental protection but also in agriculture, horticulture, space science, and plant stress biology. Much current understanding of the effects of IR on plants derives from acute h... Read More about Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation.

A grain rot of rice in Iran caused by a Xanthomonas strain closely related to X. sacchari (2020)
Journal Article

Rice grain rot disease was detected for the first time in Mazandaran Province, Iran. The bacteria isolated from infected rice plants showed grains rotted and darkening. A Xanthomonas strain closely connected to X. sacchari was identified using molecu... Read More about A grain rot of rice in Iran caused by a Xanthomonas strain closely related to X. sacchari.

Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42 (2020)
Journal Article

A key challenge in the implementation of anti-metastatics as cancer therapies is the multi-modal nature of cell migration, which allows tumour cells to evade the targeted inhibition of specific cell motility pathways. The nuclear factor-kappaB (NF-κB... Read More about Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42.