Outputs (11)

Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire (2019)
Journal Article

Chimpanzees are well-known tool users, with differences reported in the tool use repertoires among communities and subspecies. Chimpanzees at most study sites exhibit some degree of stick tool use behaviour for extractive foraging, with the exception... Read More about Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire.

Reticulocyte and red blood cell deformation triggers specific phosphorylation events (2019)
Journal Article

The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a... Read More about Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies (2019)
Journal Article

Objectives: Bioreactor-based production systems have the potential to overcome limitations associated with conventional tissue engineering manufacturing methods, facilitating regulatory compliant and cost-effective production of engineered grafts for... Read More about Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements (2019)
Journal Article

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent i... Read More about Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.

Human factors and ergonomics systems-based tools for understanding and addressing global problems of the twenty-first century (2019)
Journal Article

Sustainability is a systems problem with humans as integral elements of the system. However, sustainability problems usually have a broader scope than socio-technical systems and therefore, require additional considerations. This requires a fuller in... Read More about Human factors and ergonomics systems-based tools for understanding and addressing global problems of the twenty-first century.

The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase (2019)
Journal Article

Naematolin is a biologically active sesquiterpene produced by Hypholoma species. Low titres and complex structure constrain the exploitation of this secondary metabolite. Here, we de novo sequenced the H. fasciculare genome to identify a candidate bi... Read More about The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase.

Global food safety as a complex adaptive system: Key concepts and future prospects (2019)
Journal Article

Background
Over the last few decades the food production, distribution and consumption chains have become complex as a result of globalisation and food travelling over large distances. The food supply chain is a multi-layered structure with multiple... Read More about Global food safety as a complex adaptive system: Key concepts and future prospects.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase (2019)
Journal Article

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by ho... Read More about Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.

Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease (2019)
Journal Article

The fungus Lecanicillium fungicola causes dry bubble disease in the white button mushroom Agaricus bisporus. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this patho... Read More about Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease.

Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours (2019)
Journal Article

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers.... Read More about Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.