Outputs (21)

Dementia: Your questions answered and lion's mane mushrooms in the lab (BBC Inside Health) (2025)
Digital Artefact

BBC Radio 4 show examining the science behind health matters. I was interviewed as part of a show on Alzheimer's Disease, due to my work looking at therapeutic potential of Lion's Mane mushroom (a Partnership PhD with the Bristol Fungarium)

A brief overview of the impact of avian influenza on animals (2025)
Journal Article

Avian influenza (AI) virus, and the (HPAI)H5N1 subtype in particular, is a serious problem for many wild bird populations, where devastating losses have been reported. However, AI is not restricted to bird species. Infection has been reported in comm... Read More about A brief overview of the impact of avian influenza on animals.

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression (2024)
Journal Article

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how... Read More about SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.

Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future? (2024)
Book

Animal Welfare in a Pandemic explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. During the height of the pandemic, a range of animals were infected, and many died, but this was hard to... Read More about Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future?.

Commentary: Analysis of SUMO1-conjugation at synapses (2017)
Journal Article

Fighting polyglutamine disease by wrestling with SUMO (2015)
Journal Article

Spinobulbar muscular atrophy (SBMA) is an X-linked disease characterized by degeneration of motor neurons, muscle atrophy, and progressive weakness. It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription fact... Read More about Fighting polyglutamine disease by wrestling with SUMO.

Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction (2014)
Journal Article

Protein SUMOylation is a critically important posttranslational protein modification that participates in nearly all aspects of cellular physiology. In the nearly 20 years since its discovery, SUMOylation has emerged as a major regulator of nuclear f... Read More about Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction.

SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons (2013)
Journal Article

Multiple pathways participate in the AMPA receptor trafficking that underlies long-term potentiation (LTP) of synaptic transmission. Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient... Read More about SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons.

SUMOylation, Arc and the regulation homeostatic synaptic scaling: Implications in health and disease (2012)
Journal Article

Neurons compensate for changes in network activity by altering the sensitivity of transmission across collections of synapses by up- or downregulating the number of synaptic AMPA receptors. We recently reported that, in parallel to increasing AMPA re... Read More about SUMOylation, Arc and the regulation homeostatic synaptic scaling: Implications in health and disease.