Outputs (16)

Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity (2019)
Journal Article

Three new polyketide-derived natural products, cladobotric acids G-I (1-3), and six known metabolites (4, 5, 8-11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spectroscop... Read More about Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity.

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi (2018)
Journal Article

Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crysta... Read More about Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi.

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis (2017)
Journal Article

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds... Read More about Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis.

Heterologous production of fungal maleidrides reveals the cryptic cyclization involved in their biosynthesis (2016)
Journal Article

Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a nonadride) and agnestadride A (a h... Read More about Heterologous production of fungal maleidrides reveals the cryptic cyclization involved in their biosynthesis.

Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021-an insight into the biosynthesis of maleidrides (2015)
Journal Article

The filamentous fungus Byssochlamys fulva strain IMI 40021 produces (+)-byssochlamic acid 1, its novel dihydroanalogue 2 and four related secondary metabolites. Agnestadrides A, 17 and B, 18 constitute a novel class of seven-membered ring, maleic anh... Read More about Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021-an insight into the biosynthesis of maleidrides.

The use of yellow fluorescent hybrids to indicate mating in Trypanosoma brucei (2008)
Journal Article

Background. Trypanosoma brucei undergoes genetic exchange in its insect vector, the tsetse fly, by an unknown mechanism. The difficulties of working with this experimental system of genetic exchange have hampered investigation, particularly because t... Read More about The use of yellow fluorescent hybrids to indicate mating in Trypanosoma brucei.