John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling
Competition of reactive signals and thiol modifications of proteins
Hancock, John T; Craig, Tim J.; Whiteman, Matthew
Authors
Dr Tim Craig Tim.Craig@uwe.ac.uk
Associate Professor of Neuroscience
Matthew Whiteman
Abstract
It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the reactive nitrogen species (RNS), such as nitric oxide (NO) and sulfur-based molecules, such as hydrogen sulfide (H2S). These compounds are often involved in stress responses and dysfunction of these signaling systems is often involved in disease [1-3]. This commentary discusses the interactions of such signals, which was discussed in a previous paper [3]. It was argued that all these molecules are not acting in the same manner, and that H2S was acting in a role which moderated the effects of ROS and NO.
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 2, 2017 |
Publication Date | Jan 1, 2017 |
Deposit Date | Nov 6, 2017 |
Publicly Available Date | Nov 6, 2017 |
Journal | Journal of Cell Signaling |
Print ISSN | 2576-1471 |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 4 |
Pages | 170 |
DOI | https://doi.org/10.4172/2576-1471.1000170 |
Keywords | cell signalling, reactive oxygen species, hydrogen sulphide, nitric oxide |
Public URL | https://uwe-repository.worktribe.com/output/902160 |
Publisher URL | http://dx.doi.org/10.4172/2576-1471.1000170 |
Contract Date | Nov 6, 2017 |
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