A mitotic role for BRCA1/BARD1 in tumor suppression?

Clarke, Paul R.; Sanderson, Helen S.

Abstract

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis. © 2006 Elsevier Inc. All rights reserved.

• Journal Article Type: Commentary
• Acceptance Date: Aug 3, 2006
• Online Publication Date: Nov 3, 2006
• Publication Date: Nov 3, 2006
• Deposit Date: Jun 22, 2021
• Journal: Cell
• Print ISSN: 0092-8674
• Electronic ISSN: 1097-4172
• Publisher: Elsevier (Cell Press)
• Peer Reviewed: Not Peer Reviewed
• Volume: 127
• Issue: 3
• Pages: 453-455
• DOI: https://doi.org/10.1016/j.cell.2006.10.020
• Public URL: https://uwe-repository.worktribe.com/output/7483603