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From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility

Smart, Amy; de Lacy Costello, Ben; Ratcliffe, Norman; Drabinksa, Natalia; Hewett, Keith

Authors

Amy Smart

Norman Ratcliffe Norman.Ratcliffe@uwe.ac.uk
Professor in Materials & Sensors Science

Natalia Drabinksa

Keith Hewett



Abstract

Widespread use of antibiotics has led to the development of antibiotic resistance in many pathogenic bacteria. If effective methods of alleviating this crisis are not applied, a return to high mortality and morbidity of the pre-antibiotic era could occur. A vital step is the fast and reliable identification of bacteria, leading to appropriate prescription of antimicrobial treatment. In this review, the potential of volatile compound (VC) analysis for the development of diagnostic devices for antibiotic resistance testing is presented. VC analyses have shown promise for the diagnosis of many diseases, including bacterial infections. Moreover, the role of VCs in the induction of resistance, and in microbial communication is described. Examples of recent applications of VC detection for the differentiation of sensitive and resistant bacterial strains are reported. The review outlines existing challenges which must be overcome before VC profiling becomes a viable method for the rapid detection of antibiotic resistance.

Journal Article Type Review
Acceptance Date Mar 24, 2019
Online Publication Date Mar 29, 2019
Publication Date Jun 1, 2019
Deposit Date Nov 26, 2020
Journal TrAC - Trends in Analytical Chemistry
Print ISSN 0165-9936
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 115
Pages 1-12
DOI https://doi.org/10.1016/j.trac.2019.03.019
Keywords Antibiotic susceptibilityAntibiotic resistant bacteriaVolatile organic compoundsBacterial infection diagnosisMetabolic fingerprinting
Public URL https://uwe-repository.worktribe.com/output/6898949