Nitric oxide, other reactive signalling compounds, redox, and reductive stress

Hancock, John; Veal, David

Abstract

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used in signalling are generated and accumulate spatially and temporally together. This includes the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), and hydrogen sulfide (H2S). Here, the interactions with such other reactive molecules is briefly reviewed. Furthermore, along with ROS and H2S, NO will potentially contribute to the overall intracellular redox of the cell. However, RNS will exist in redox couples and therefore the influence of the cellular redox on such couples will be explored. In discussions of the aberrations in intracellular redox it is usually oxidation, so-called oxidative stress, which is discussed. Here, we consider the notion of reductive stress and how this may influence the signalling which may be mediated by NO. By getting a more holistic view of NO biology, the influence on cell activity of NO and other RNS can be more fully understood, and may lead to the elucidation of methods for NO-based manipulation of plant physiology, leading to better stress responses and improved crops in the future.

• Journal Article Type: Review
• Acceptance Date: Jul 9, 2020
• Online Publication Date: Jul 20, 2020
• Publication Date: Feb 11, 2021
• Deposit Date: Jul 10, 2020
• Publicly Available Date: Jul 21, 2021
• Journal: Journal of Experimental Botany
• Print ISSN: 0022-0957
• Electronic ISSN: 1460-2431
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 72
• Issue: 3
• Pages: 819-829
• DOI: https://doi.org/10.1093/jxb/eraa331
• Keywords: Glutathione; Hydrogen peroxide; Hydrogen sulfide; NAD(P)H; Nitric oxide; Reactive oxygen species; Redox; Reductive stress
• Public URL: https://uwe-repository.worktribe.com/output/6231528
• Publisher URL: https://academic.oup.com/jxb