ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?

Vahabi, Bahareh; Jabr, Rita; Fry, Chris; McCloskey, Karen; Everaert, Karel; Agudelo, Christina W.; Monaghan, Thomas F.; Rahnama'i, Mohammad S.; Panicker, Jalesh N.; Weiss, Jeffrey P.

Abstract

Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether nocturia is a circadian disorder; (c) to discuss the role of melatonin in nocturia; (d) to consider ambulatory urodynamic monitoring in evaluating patients with nocturia; (e) to explore studies of water handling in human compartments utilizing heavy water; and (f) to explore whether basic science is the key to understanding the treatment options for diminished bladder capacity in patients with nocturia. Methods: A compendium of discussions of the role of experimental science in understanding the pathophysiology of nocturia is described herein. Results and Conclusions: Translational science will play an increasing role in understanding the pathophysiology of nocturia, which may result in improved treatment strategies.

• Journal Article Type: Review
• Acceptance Date: Dec 30, 2019
• Online Publication Date: Jan 10, 2020
• Publication Date: Jul 14, 2020
• Deposit Date: Feb 10, 2020
• Journal: Neurourology and Urodynamics
• Print ISSN: 0733-2467
• Electronic ISSN: 1520-6777
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Issue: S3 Supplement: ICI‐RS 2019
• Pages: S88-S95
• DOI: https://doi.org/10.1002/nau.24274
• Keywords: Urology, clinical neurology, circadian rhythm, nocturia, nocturnal polyuria (NP), urodynamics, water handling
• Public URL: https://uwe-repository.worktribe.com/output/5350700
• Additional Information: Received: 2019-09-12; Accepted: 2019-12-30; Published: 2020-01-10