Kinetic resolution of the chiral iron acetyl [Fe(η5-C5H5)(CO)(PPh3)COMe]

Hedgecock, Charles J.R.; Prime, Jeremy C.; Case-Green, Stephen C.; Costello, James F.; Davies, Stephen G.; Hedgecock, Charles J. R.; Heaton, Nicholas; Primes, Jeremy C.

Abstract

The chiral discrimination displayed between the enolate derived from (RS)-[Fe(η5-C5H5)(CO)(PPh3)COMe] and (1R)-(+)-camphor furnishes a practical route to homochiral (R)-[Fe(η5-C5H5)(CO)(PPh3)COMe] via a kinetic resolution protocol, while a retro-aldol reaction of the diastereoisomerically pure aldol addition product of this kinetic resolution sequence provides a complementary route to the opposite enantiomer (S)-[Fe(η5-C5H5)(CO)(PPh3)COMe].

• Journal Article Type: Article
• Publication Date: Dec 1, 1993
• Journal: Journal of the Chemical Society, Chemical Communications
• Print ISSN: 0022-4936
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 21
• Pages: 1621-1622
• DOI: https://doi.org/10.1039/C39930001621
• Keywords: kinetic resolution, chiral iron acetyl
• Public URL: https://uwe-repository.worktribe.com/output/1109509
• Publisher URL: http://dx.doi.org/10.1039/C39930001621