Gene libraries: Coverage, efficiency and diversity

Cayzer, Steve; Smith, Jim

Abstract

Gene libraries are a biological mechanism for generating combinatorial diversity in the immune system. However, they also bias the antibody creation process, so that they can be viewed as a way of guiding lifetime learning mechanisms. In this paper we examine the implications of this view, by examining coverage, avoidance of self, clustering and diversity. We show how gene libraries may improve both computational expense and performance, and present an analysis which suggests how they might do it. We suggest that gene libraries: provide combinatorial efficiency; improve coverage; reduce the cost of negative selection; and allow targeting of fixed antigen populations.

• Presentation Conference Type: Conference Paper (published)
• Conference Name: International Conference on Artificial Immune Systems
• Start Date: Sep 4, 2006
• End Date: Sep 6, 2006
• Publication Date: Jan 1, 2006
• Pages: 136-149
• Series Title: Lecture Notes in Computer Science
• Series Number: 4163
• Series ISSN: 0302-9743
• Book Title: Artificial Immune Systems. ICARIS 2006
• ISBN: 9783540377498
• DOI: https://doi.org/10.1007/11823940_11
• Keywords: computation by abstract devices, artificial intelligence, algorithm analysis and problem complexity, database management, information storage and retrieval, bioinformatics gene libraries, artificial immune systems, antibodies, diversity, Baldwin effect, l
• Public URL: https://uwe-repository.worktribe.com/output/1043184
• Publisher URL: http://dx.doi.org/10.1007/11823940_11