Outputs (1721)

Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease (2023)
Thesis

Introduction: Oxidative stress and impaired homeostasis are key features of type 2 diabetes mellitus, which is comorbid with Alzheimer’s disease. Dysregulation of the branched-chain aminotransferase protein, which is overexpressed in AD, is suggested... Read More about Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease.

Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements (2023)
Presentation / Conference Contribution

Preventing infections in joint replacements is a major ongoing challenge, with limited effective clinical technologies currently available for uncemented knee and hip prostheses. This research aims to develop a coating for titanium implants, consisti... Read More about Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements.

Human stem cell-derived ventral midbrain astrocytes exhibit a region-specific secretory profile (2023)
Journal Article

This scientific commentary refers to ‘Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles’, by Clarke et al. (https://doi.org/10.1093/brain/awaa258) in Brain.

Promoting dietary changes for achieving health and sustainability targets (2023)
Journal Article

Globally, about 21–37% of total greenhouse gas (GHG) emissions are attributable to food systems. Dietary-related non-communicable diseases have increased significantly from 1990–2019 at a global scale. To achieve carbon emissions targets, increase re... Read More about Promoting dietary changes for achieving health and sustainability targets.

The on/off history of hydrogen in medicine: Will the interest persist this time around? (2023)
Journal Article

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the da... Read More about The on/off history of hydrogen in medicine: Will the interest persist this time around?.

The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

Slow violence and river abuse: The hidden effect of land use on water quality (2023)
Exhibition / Performance

Researchers from HAS, Dr Gillian Clayton and Professor Darren Reynolds (HAS) and Researchers from ACE Niamh Fahy and Associate Professor Sarah Bodman have been collaborating on a project in Somerset, UK, from which Niamh is using data and samples col... Read More about Slow violence and river abuse: The hidden effect of land use on water quality.

Description of Dryocola gen. nov. and two novel species, Dryocola boscaweniae sp. nov. and Dryocola clanedunensis sp. nov. isolated from the rhizosphere of native British oaks (2023)
Journal Article

While investigating the role of the rhizosphere in the development of Acute Oak Decline, bacterial strains belonging to the family Enterobacteriaceae were isolated from rhizosphere soil following enrichment for the Enterobacterales. Partial sequencin... Read More about Description of Dryocola gen. nov. and two novel species, Dryocola boscaweniae sp. nov. and Dryocola clanedunensis sp. nov. isolated from the rhizosphere of native British oaks.

Variations in bacteriological and physicochemical water quality characteristics of Asata River, Enugu, Nigeria (2023)
Journal Article

Background and Objective: Globally, river water remains an important source of water for drinking, domestic and other uses. This study aimed to assess the bacteriological and physicochemical properties of Asata River water. Materials and Methods: A... Read More about Variations in bacteriological and physicochemical water quality characteristics of Asata River, Enugu, Nigeria.

The control of pathogens in stored rainwater using direct electrochemical activation (2022)
Presentation / Conference Contribution

Purpose of study or research hypothesis: The main study aim was to control waterborne pathogens using small-scale direct electrochemical activation.

Key issue(s) or problem(s) addressed: Rainwater harvesting systems enable households o... Read More about The control of pathogens in stored rainwater using direct electrochemical activation.

What drives bat activity at field boundaries? (2022)
Journal Article

Field boundaries are important habitat for bats in agricultural landscapes, serving as commuting and foraging areas for many species. The goal of our study was to better understand the drivers of bat activity in agricultural landscapes to inform cons... Read More about What drives bat activity at field boundaries?.

Managing biofilms in ultrafiltration membranes within a point-of-use drinking water system (2022)
Presentation / Conference Contribution

Description of a novel species of Leclercia, Leclercia tamurae sp. nov. and proposal of a novel genus Silvania gen. nov. containing two novel species Silvania hatchlandensis sp. nov. and Silvania confinis sp. nov. isolated from the rhizosphere of oak (2022)
Journal Article

Background: Acute Oak Decline (AOD) is a decline disease first reported on native oaks in the UK, but in recent years reports from further afield such as Europe and the Middle East, indicate that the distribution and host range is increasing at an al... Read More about Description of a novel species of Leclercia, Leclercia tamurae sp. nov. and proposal of a novel genus Silvania gen. nov. containing two novel species Silvania hatchlandensis sp. nov. and Silvania confinis sp. nov. isolated from the rhizosphere of oak.

Clean water for all (2022)
Digital Artefact

The World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) estimated that, as of 2020, 2 billion people across the globe did not have access to safely managed drinking water.

Ideally, safely managed drinking water should b... Read More about Clean water for all.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Environmental assessment of coal mine drainage from historical mining in Bristol and South Gloucestershire (2022)
Presentation / Conference Contribution

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

Systematic review of surveillance systems for AMR in Africa (2022)
Journal Article

AIMS: Surveillance is a useful tool for tracking antimicrobial resistance (AMR) trends, patterns, therapeutic and policy interventions. Proper correlation of surveillance data gives meaningful insight into the underlying epidemiology and facilitates... Read More about Systematic review of surveillance systems for AMR in Africa.

Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus (2022)
Journal Article

Antibacterial bone biomaterial coatings appeal to orthopaedics, dentistry and veterinary medicine. Achieving the successful, stable conjugation of suitable compounds to biomaterial surfaces is a major challenge. A pragmatic starting point is to make... Read More about Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.