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Outputs (1343)

The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease (2014)
Thesis

Introduction & Aims: The distribution of the BCAT proteins has been extensively mapped in rodent models, and metabolic studies have established that BCAT transamination in the rodent brain is responsible for 30% of de novo glutamate synthesis. Howeve... Read More about The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease.

An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo (2014)
Thesis

Introduction Triple negative breast cancers are defined by their lack of expression of HER, oestrogen receptors and progesterone receptors. They account for around 10-24% of cases. To define a cancer by the biomarkers it does not express is unsati... Read More about An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo.

Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis (2014)
Journal Article

It has been suggested that mixing alcohol with energy drinks or other caffeinated beverages may alter the awareness of (or 'mask') intoxication. The proposed reduction in subjective intoxication may have serious consequences by increasing the likelih... Read More about Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis.

A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements (2014)
Journal Article

High density lipoprotein cholesterol (HDL-C) is a modifiable risk factor in cardiovascular disease and devices suitable for its determination at the point of care are critical to the future management of hypercholesterolaemia. An electrochemical bios... Read More about A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements.

Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells (2014)
Journal Article

In this study, we investigate the potential for oral Lactobacilli (LB) to afford innate protection against nasopharyngeal coloniser Neisseria meningitidis serogroup B (NmB), which causes the bulk of UK meningococcal disease. Oral isolates of L. plant... Read More about Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells.

Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations (2014)
Journal Article

Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are... Read More about Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations.

Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival (2014)
Thesis

Introduction: Diabetes affects more than 346 million individuals worldwide. Some 90% of diabetics have type 2 diabetes mellitus, which is frequently associated with obesity and hyperlipidemia as well as hyperglycaemia. There is ample evidence that... Read More about Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival.

Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography (2013)
Journal Article

The kinetic performance of a bare silica and C18 phase prepared from the same sub-2. μm and 3.5. μm base materials were compared in the HILIC and RP mode using both charged and neutral solutes. The HILIC column was characterised using the neutral sol... Read More about Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography.

Introduction (2014)
Book Chapter

Nano-scale materials are proving attractive for a new generation of devices, due to their unique properties. They are used to create fast-responding sensors with good sensitivity and selection for the detection of chemical species and biological agen... Read More about Introduction.

The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells
Thesis

Introduction: The hBCAT proteins have a unique redox active CXXC motif which governs its transamination activity. Recent studies have identified that specific neuronal proteins with either redox activity or functions in cell signalling form interac... Read More about The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells.