Dr Tim Craig's Outputs (3)

SUR1: A unique ATP-binding cassette protein that functions as an ion channel regulator (2008)
Journal Article

SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive (KATP) channel is an octameric complex of four pore-forming Kir6.2 su... Read More about SUR1: A unique ATP-binding cassette protein that functions as an ion channel regulator.

How ATP inhibits the open KATP channel (2008)
Journal Article

ATP-sensitive potassium (KATP) channels are composed of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits. Binding of ATP to Kir6.2 leads to inhibition of channel activity. Because there are four subunits and thus four ATP-binding s... Read More about How ATP inhibits the open KATP channel.

Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation (2008)
Journal Article

Aims: Heterozygous activating mutations in KCNJ11, which encodes the Kir6.2 subunit of the pancreatic ATP-sensitive potassium (K(ATP)) channel, cause both permanent and transient neonatal diabetes. Identification of KCNJ11 mutations has important the... Read More about Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation.