Dr Tim Craig's Outputs (2)

SUMOylation, Arc and the regulation homeostatic synaptic scaling: Implications in health and disease (2012)
Journal Article

Neurons compensate for changes in network activity by altering the sensitivity of transmission across collections of synapses by up- or downregulating the number of synaptic AMPA receptors. We recently reported that, in parallel to increasing AMPA re... Read More about SUMOylation, Arc and the regulation homeostatic synaptic scaling: Implications in health and disease.

Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation (2012)
Journal Article

Background: SUMOylation regulates many cell pathways.
Results: Synaptic scaling elicited by suppression of neuronal activity decreases the deSUMOylating enzyme SENP1; overexpression of SENP1 prevents synaptic scaling.
Conclusion: SUMOylation is req... Read More about Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation.