Mark Lyttle's Outputs (17)

Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study (2019)
Journal Article

Aim
To characterise the causes, clinical characteristics and short‐term outcomes of neonates who presented to paediatric emergency departments with a head injury.

Methods
Secondary analysis of a prospective data set of paediatric head injuries a... Read More about Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study.

Research without prior consent in paediatric emergency and critical care medicine (2019)
Journal Article

Children and young peoples' healthcare should be evidence-based yet many treatments are unlicensed or prescribed off-label. Research is needed, but prospective informed consent for many emergency and critical care trials is neither feasible nor ethic... Read More about Research without prior consent in paediatric emergency and critical care medicine.

Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017 (2019)
Journal Article

Objectives
Trauma contributes significantly to adolescent morbidity and mortality. We aimed to ascertain the epidemiology of adolescent trauma to inform prevention strategies.

Methods
Data were abstracted from TARN (Trauma Audit Research Network... Read More about Epidemiology of adolescent trauma in England: A review of TARN data 2008-2017.

Performance of two head injury decision rules evaluated on an external cohort of 18,913 children (2019)
Journal Article

The Pediatric Emergency Care Applied Research Network (PECARN) decision rule demonstrates high sensitivity for identifying children at low risk for clinically important traumatic brain injury (ciTBI). As with the PECARN rule, the Israeli Decision Alg... Read More about Performance of two head injury decision rules evaluated on an external cohort of 18,913 children.

Clinically important sport‐related traumatic brain injuries in children (2019)
Journal Article

Sports participation by children and adolescents is generally high in Australia and New Zealand,1, 2 and many children sustain head injuries of varying severity during such activities. Concussion has received increasing attention, but less is known a... Read More about Clinically important sport‐related traumatic brain injuries in children.

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial (2019)
Journal Article

Background
Pain from injuries is one of the commonest symptoms in children attending emergency departments (EDs), and this is often inadequately treated in both the pre-hospital and ED settings, in part due to challenges of continual assessment and... Read More about Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children - The MAGPIE trial (MEOF-002): Study protocol for a randomised controlled trial.

Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland (2019)
Journal Article

Introduction Mobile devices and medical apps are used by healthcare professionals in adult and paediatric emergency departments worldwide. Recently, there has been a drive toward increased digitalisation especially in the UK. This point prevalence su... Read More about Mobile device and app use in paediatric emergency care: A survey of departmental practice in the UK and Ireland.

Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis (2019)
Journal Article

Objective: To identify parents' prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection. Design: Qualitative synthesis combining parent interview data from t... Read More about Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: A qualitative synthesis.

Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis (2019)
Journal Article

Background
Clinical guidelines advise against pharmacotherapy in bronchiolitis. However, little is known about global variation in prescribing practices for bronchiolitis at discharge from emergency departments. We aimed to evaluate global variation... Read More about Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric Emergency Research Networks: A retrospective analysis.

Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC) (2019)
Journal Article

Objective: The Petechiae in Children (PiC) study assesses the utility of presenting features and rapid diagnostic tests in the diagnosis of serious bacterial infection in feverish children with non-blanching rashes. An embedded qualitative study expl... Read More about Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: Qualitative insight from the Petechiae in Children study (PiC).

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT) (2019)
Journal Article

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Community-acquired pneumonia (CAP) is a common indication for antibiotic treatment in young children. Data are limited regarding the ideal dose and... Read More about Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia: A protocol for a randomIsed controlled Trial (CAP-IT).

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article

Background
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (2019)
Journal Article

Background: EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention... Read More about Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study.

Traumatic brain injury in young children with isolated scalp haematoma (2019)
Journal Article

Objective Despite high-quality paediatric head trauma clinical prediction rules, the management of otherwise asymptomatic young children with scalp haematomas (SH) can be difficult. We determined the risk of intracranial injury when SH is the only pr... Read More about Traumatic brain injury in young children with isolated scalp haematoma.

Incidence of medically attended paediatric burns across the UK (2019)
Journal Article

Objective: Childhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and death... Read More about Incidence of medically attended paediatric burns across the UK.

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis (2019)
Journal Article

Background
Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants

Delayed presentations to emergency departments of children with head injury: A PREDICT study (2019)
Journal Article

© 2018 American College of Emergency Physicians Study objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We... Read More about Delayed presentations to emergency departments of children with head injury: A PREDICT study.