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Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1 (2018)
Journal Article

Copyright © 2018 American Chemical Society. Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis. Thus... Read More about Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.

Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide (2018)
Journal Article

© 2018 American Chemical Society. The overexpression of α-synuclein (α-syn) and its aggregation is the hallmark of Parkinson's disease. The α-syn aggregation results in the formation of Lewy bodies that causes neuronal cell death. Therefore, the smal... Read More about Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide.

Industrial or traditional bamboo construction? Comparative life cycle assessment (LCA) of bamboo-based buildings (2018)
Journal Article

© 2018 by the authors. The past five decades have witnessed an unprecedented growth in population. This has led to an ever-growing housing demand. It has been proposed that the use of bio-based materials, and specifically bamboo, can help alleviate t... Read More about Industrial or traditional bamboo construction? Comparative life cycle assessment (LCA) of bamboo-based buildings.

Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme (2018)
Journal Article

© Copyright 2018 American Chemical Society. CYP2D6, a cytochrome P450 (CYP) enzyme, metabolizes codeine to morphine. Within the human body, 0-15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine.... Read More about Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme.

Epilogue: the new frontiers of behavioral research on the interrelationships between ICT, activities, time use and mobility (2018)
Journal Article

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. This special issue is a product of the international symposium on “ICT, Activities, Time Use and Travel” that was hosted by Nanjing University from 16 to 18 July 2016. The symposi... Read More about Epilogue: the new frontiers of behavioral research on the interrelationships between ICT, activities, time use and mobility.

Bridging the gap: A case study of a partnership approach to skills development through student engagement in bristol’s green capital year (2018)
Journal Article

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. HEIs are well placed to engage with local communities, and can connect students with organisations through several pathways, such as volunteering opportunitie... Read More about Bridging the gap: A case study of a partnership approach to skills development through student engagement in bristol’s green capital year.

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme (2017)
Journal Article

© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With a... Read More about Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent (2017)
Journal Article

The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones were... Read More about (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme (2017)
Journal Article

© 2017 American Chemical Society. Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessin... Read More about Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

The dynamics of urban metabolism in the face of digitalization and changing lifestyles: Understanding and influencing our cities (2017)
Journal Article

© 2017 Elsevier B.V. The world's population continues to grow. With a trend of urbanisation apparent, increasing attention is now being given to understanding and shaping our cities to support an evolving society. Urban metabolism concerns the flows... Read More about The dynamics of urban metabolism in the face of digitalization and changing lifestyles: Understanding and influencing our cities.

The Bristol Art Library (2017)
Journal Article

This is a visual essay that analyses the changing function of the public space of the library through the juxtaposition of image and text. It looks at The Bristol Art Library, a performance space and fully functioning library, housed in a wooden cabi... Read More about The Bristol Art Library.