All Outputs (474)

A decision-making model for public health authorities in circumstances of potentially high public risk (2025)
Journal Article

Background
An expert multidisciplinary panel was commissioned by a UK Health Security Agency led incident management team (IMT) to support decision making in the case of an individual with extensively drug-resistant tuberculosis. The behaviour and s... Read More about A decision-making model for public health authorities in circumstances of potentially high public risk.

Magnet ingestion in children in the United Kingdom: A national prospective observational surveillance study (2025)
Journal Article

Background
Magnet ingestion in children and young people (CYP) associates with significant harm. The incidence and circumstances of magnet ingestions in CYP are unknown in the United Kingdom (UK). We aimed to determine these and report associated ou... Read More about Magnet ingestion in children in the United Kingdom: A national prospective observational surveillance study.

What is currently known about female genital mutilation and incontinence: A narrative literature review (2025)
Journal Article

Background: An estimated 230 million girls and women are living with female genital mutilation (FGM) which causes ongoing physical and psychological harm. This review aims to explore what is known about FGM and incontinence, including the underexamin... Read More about What is currently known about female genital mutilation and incontinence: A narrative literature review.

Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experience: The SPIN-CLEAR Trials (2025)
Journal Article

Background
Research results are often not communicated to study participants or others with relevant lived experience. Effective communication of research results would help study participants understand their contribution to research and could impr... Read More about Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experience: The SPIN-CLEAR Trials.

Inner strength or outer armour? Lived experiences of what supports health and wellbeing in young people who have experienced childhood adversity (2025)
Thesis

The groundbreaking study by Felitti et al (1998) linking Adverse Childhood Experiences (ACEs) to ill health, adversity and trauma laid the foundation for a wide array of subsequent studies exploring the connections between childhood adversity, trauma... Read More about Inner strength or outer armour? Lived experiences of what supports health and wellbeing in young people who have experienced childhood adversity.

Emergency department interventions and their effect on subsequent healthcare resource use after discharge: An overview of systematic reviews (2025)
Journal Article

Background: Due to the worldwide pressures on Emergency Departments (EDs), there is a focus on ED interventions to alleviate pressure. Ensuring interventions do not inadvertently impact upon other healthcare sectors is an important outcome. This over... Read More about Emergency department interventions and their effect on subsequent healthcare resource use after discharge: An overview of systematic reviews.

Psychometric validation and scale derivation of the ICIQ-Underactive Bladder patient reported outcome measure (2025)
Journal Article

Aims
To complete the psychometric validation and scale derivation of the International Consultation on Incontinence Questionnaire-Underactive Bladder (ICIQ-UAB).
Methods
The developmental ICIQ-UAB was administered within a Phase II randomised con... Read More about Psychometric validation and scale derivation of the ICIQ-Underactive Bladder patient reported outcome measure.

Development and content validity of the Musculoskeletal Self-Management Questionnaire (MSK-SMQ) (2025)
Journal Article

Background
Self-management is recommended for managing persistent musculoskeletal conditions. In self-management, standardized and validated measurements (e.g., questionnaires) should be used. However, there is no... Read More about Development and content validity of the Musculoskeletal Self-Management Questionnaire (MSK-SMQ).

Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: A national cohort study in China (2025)
Journal Article

Background: The accumulation of heavy metals in surface soil raises significant environmental and public health concerns around the world. This study aimed to examine the relationship between exposure to heavy metals in surface soil and the risk of p... Read More about Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: A national cohort study in China.

OA34 The contributions of Patient and Public Involvement and Engagement groups to the conduct of a scoping review of non-pharmacological interventions for reducing fatigue in children and young people with musculoskeletal conditions (2025)
Presentation / Conference Contribution

Background/Aims Fatigue is an important symptom for people of all ages with musculoskeletal (MSK) conditions. This includes the 234,000 children and young people (CYP) in England and Scotland currently living with conditions such as juvenile inflamma... Read More about OA34 The contributions of Patient and Public Involvement and Engagement groups to the conduct of a scoping review of non-pharmacological interventions for reducing fatigue in children and young people with musculoskeletal conditions.

Pain management training for people with persistent pain and their informal carers (JOINT SUPPORT): Multicentre randomised controlled feasibility trial with embedded qualitative study in English musculoskeletal services (2025)
Journal Article

Objectives: To assess the feasibility of conducting a pragmatic, multicentre randomised controlled trial (RCT) to test the clinical and cost-effectiveness of a pain management training intervention to support people with persistent musculoskeletal pa... Read More about Pain management training for people with persistent pain and their informal carers (JOINT SUPPORT): Multicentre randomised controlled feasibility trial with embedded qualitative study in English musculoskeletal services.

Assessing barriers and opportunities for the improvement of laboratory performance and robust surveillance of antimicrobial resistance in Nigeria– a quantitative study (2025)
Journal Article

Background: Good quality data is essential in optimising containment strategies for antimicrobial resistance, a global public health threat estimated to cause around 10 million deaths yearly and up-to 5% loss in GDP by 2050 if left unaddressed. The l... Read More about Assessing barriers and opportunities for the improvement of laboratory performance and robust surveillance of antimicrobial resistance in Nigeria– a quantitative study.

Predictors of persisting symptoms after concussion in children following a traumatic brain injury: A longitudinal retrospective cohort study (2025)
Journal Article

Objectives: To identify predictors of persisting symptoms after concussion (PSaC) in children, following any medically attended traumatic brain injury (TBI). Design: Retrospective cohort study. Setting: Linked primary and secondary care data from UK... Read More about Predictors of persisting symptoms after concussion in children following a traumatic brain injury: A longitudinal retrospective cohort study.

Heart failure and participation in physical activity (The HAPPY + study): Health professional support and availability of community physical activity services (2025)
Presentation / Conference Contribution

Abstract

Background Nearly 1 million people in the UK are living with heart failure (HF). Most people diagnosed with HF are managed in primary care. Physical activity can increase wellbeing, reduce hospitalisation and improve mortality rates for... Read More about Heart failure and participation in physical activity (The HAPPY + study): Health professional support and availability of community physical activity services.

Prescribing metformin for patients with non-diabetic hyperglycaemia or type 2 diabetes (2025)
Journal Article

Metformin hydrochloride is a prescription-only oral medicine that is frequently encountered in clinical practice. It is recommended in most diabetes mellitus guidelines as a first-line treatment option for some people with non-diabetic hyperglycaemia... Read More about Prescribing metformin for patients with non-diabetic hyperglycaemia or type 2 diabetes.

Physical activity support for people with heart failure: mixed-methods study protocol (2025)
Journal Article

Heart failure (HF) is a common condition affecting 1-2 in every hundred adults in the UK and one in six people aged over 85 years. Physical activity is important for people with HF (PWHF) as it can increase exercise capacity and is shown to improve q... Read More about Physical activity support for people with heart failure: mixed-methods study protocol.

From classroom to clinic: Innovating radiotherapy treatment planning education through real-world end-to-end case study simulation with an anthropomorphic phantom (2025)
Journal Article

The incorporation of simulation-based learning in healthcare education, particularly in radiotherapy, is necessary for enhancing training and professional competencies to serve patient safety and treatment accuracy. This study aimed to incorporate an... Read More about From classroom to clinic: Innovating radiotherapy treatment planning education through real-world end-to-end case study simulation with an anthropomorphic phantom.

A centre specific Quality Improvement Project (QIP) to decrease ‘temperature spike to needle time’ for first dose empiric antibiotics to within 60 minutes for inpatients in a haematology and autologous stem cell transplant unit within a UK District General Hospital (2025)
Presentation / Conference Contribution

Background

Neutropenic sepsis following systemic anti-cancer therapy and autologous stem cell transplant is a life-threatening emergency, with a mortality rate of 40% among haematology patients (Klastersky et al 2016, NICE 2024), due to deeper and... Read More about A centre specific Quality Improvement Project (QIP) to decrease ‘temperature spike to needle time’ for first dose empiric antibiotics to within 60 minutes for inpatients in a haematology and autologous stem cell transplant unit within a UK District General Hospital.

A global call to action for disability inclusion in health research (2025)
Journal Article

Despite bringing great strengths and facing substantial health inequities, disabled people remain underserved by health research; addressing this requires multi-level actions spanning all areas of research.

Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: A multicentre, superiority, parallel, open-label, randomised controlled trial (2025)
Journal Article

Overactive bladder is a common problem affecting women worldwide, with a negative effect on their social and professional lives. Before considering invasive treatments, guidelines recommend urodynamics to identify detrusor overactivity. However, the... Read More about Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: A multicentre, superiority, parallel, open-label, randomised controlled trial.