All Outputs (273)

Radioactivity in future phosphogypsum: New predictions based on estimates of ‘Peak P’ and rock phosphate resources (2022)
Journal Article

Global food supplies currently depend on producing inorganic P fertilisers from a finite reserve of rock phosphate (RP). P fertilisers are themselves significant pollutants but their production from RP also leaves a phosphogypsum (PG) by-product that... Read More about Radioactivity in future phosphogypsum: New predictions based on estimates of ‘Peak P’ and rock phosphate resources.

Early experience with MR‐guided adaptive radiotherapy using a 1.5 T MR‐Linac: First 6 months of operation using adapt to shape workflow (2021)
Journal Article

Introduction
The magnetic resonance linear accelerator (MRL) offers improved soft tissue visualization to guide daily adaptive radiotherapy treatment. This manuscript aims to report initial experience using a 1.5 T MRL in the first 6 months of opera... Read More about Early experience with MR‐guided adaptive radiotherapy using a 1.5 T MR‐Linac: First 6 months of operation using adapt to shape workflow.

The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder (2021)
Journal Article

Purpose: The urinary bladder generates phasic contractions via action potentials generated in pre- and then postganglionic neurons. Whilst the frequency-dependence of postganglionic neurons to generate contractions has been quantified, the dynamic ra... Read More about The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder.

Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s (2021)
Report

This guideline covers the diagnosis and management of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), obesity hypoventilation syndrome (OHS) and chronic obstructive pulmonary disease with OSAHS (COPD–OSAHS overlap syndrome) in people over 16. It... Read More about Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s.

Core steps to the Azaphilone family of fungal natural products (2021)
Journal Article

Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed con... Read More about Core steps to the Azaphilone family of fungal natural products.

Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model (2021)
Journal Article

Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes B... Read More about Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model.

Band 3, an essential red blood cell hub of activity (2021)
Journal Article

The red blood cell (RBC) is a marvel of cellular evolutionary specialization. Whilst often considered simplistic owing to its absence of nuclei and other cellular organelles, this inability to respond transcriptionally and to replenish components thr... Read More about Band 3, an essential red blood cell hub of activity.

The discovery of a novel antimetastatic Bcl3 inhibitor (2021)
Journal Article

The development of antimetastatic drugs is an urgent healthcare priority for patients with cancer, because metastasis is thought to account for around 90% of cancer deaths. Current antimetastatic treatment options are limited and often associated wit... Read More about The discovery of a novel antimetastatic Bcl3 inhibitor.

FLASH proton therapy (2021)
Presentation / Conference Contribution

Conference teaching session: The FLASH effect is a normal tissue sparing induced by ultra-high dose rate irradiation. This effect has the potential to create a step change in the therapeutic ratio, however the exact parameters which induce normal tis... Read More about FLASH proton therapy.

Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites (2021)
Journal Article

The use of filamentous fungi as cellular factories, where natural product pathways can be refactored and expressed in a host strain, continues to aid the field of natural product discovery. Much work has been done to develop host strains which are ge... Read More about Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites.

The PTEN conundrum: How to target PTEN-deficient prostate cancer (2020)
Journal Article

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to advanced prostate cancer progression and poor clinical outcome. Accordingly, se... Read More about The PTEN conundrum: How to target PTEN-deficient prostate cancer.

Biodistribution PET/CT study of Hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice (2020)
Journal Article

Proteins, as a major component of organisms, are considered the preferred biomaterials for drug delivery vehicles. Hemoglobin (Hb) has been recently rediscovered as a potential drug carrier, but its use for biomedical applications still lacks extensi... Read More about Biodistribution PET/CT study of Hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice.

Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning (2020)
Journal Article

Haemolytic anaemias arise when red blood cell (RBC) integrity is compromised, eventually resulting in premature clearance or lysis and leading to anaemia when these effects cannot be sufficiently compensated by the capacity of the bone marrow to prod... Read More about Rapid diagnosis of hereditary haemolytic anaemias using automated rheoscopy and supervised machine learning.

The metabolic profiles and bacterial interactions of Bacteroides fragilis, Salmonella enterica serovar Typhimurium, E. coli Nissle 1917 and Clostridium perfringens on RG/C2 (benign) and HCT116 (malignant) colorectal tumour cell lines (2020)
Presentation / Conference Contribution

The aim of this research was to determine the interaction of the afore mentioned bacterial species on the attachment and invasion of both benign and malignant tumour cells using the gentamicin and metronidazole bacterial infection assay. The results... Read More about The metabolic profiles and bacterial interactions of Bacteroides fragilis, Salmonella enterica serovar Typhimurium, E. coli Nissle 1917 and Clostridium perfringens on RG/C2 (benign) and HCT116 (malignant) colorectal tumour cell lines.

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis (2020)
Journal Article

Dehydrated hereditary stomatocytosis 1 or hereditary xerocytosis (HX, OMIM 194380) is a rare hereditary autosomal dominant disorder characterized by hemolytic anemia and red blood cell (RBC) dehydration. The occurrence of HX is linked with gain-of-fu... Read More about PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis.

Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation (2020)
Journal Article

The effects of ionising radiation (IR) on plants are important for environmental protection but also in agriculture, horticulture, space science, and plant stress biology. Much current understanding of the effects of IR on plants derives from acute h... Read More about Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation.

Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42 (2020)
Journal Article

A key challenge in the implementation of anti-metastatics as cancer therapies is the multi-modal nature of cell migration, which allows tumour cells to evade the targeted inhibition of specific cell motility pathways. The nuclear factor-kappaB (NF-κB... Read More about Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42.

Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire (2019)
Journal Article

Chimpanzees are well-known tool users, with differences reported in the tool use repertoires among communities and subspecies. Chimpanzees at most study sites exhibit some degree of stick tool use behaviour for extractive foraging, with the exception... Read More about Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire.

Reticulocyte and red blood cell deformation triggers specific phosphorylation events (2019)
Journal Article

The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a... Read More about Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements (2019)
Journal Article

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent i... Read More about Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.