Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity

Dao, Trong Tuan; Williams, Katherine; De Mattos-Shipley, Kate M.J.; Song, Zhongshu; Takebayashi, Yuiko; Simpson, Thomas J.; Spencer, James; Bailey, Andrew M.; Willis, Christine L.

doi:10.1021/acs.jnatprod.1c01063

All Outputs (8)

Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire (2019)
Journal Article

Chimpanzees are well-known tool users, with differences reported in the tool use repertoires among communities and subspecies. Chimpanzees at most study sites exhibit some degree of stick tool use behaviour for extractive foraging, with the exception... Read More about Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire.

Reticulocyte and red blood cell deformation triggers specific phosphorylation events (2019)
Journal Article

The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a... Read More about Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements (2019)
Journal Article

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent i... Read More about Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.

The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase (2019)
Journal Article

Naematolin is a biologically active sesquiterpene produced by Hypholoma species. Low titres and complex structure constrain the exploitation of this secondary metabolite. Here, we de novo sequenced the H. fasciculare genome to identify a candidate bi... Read More about The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase (2019)
Journal Article

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by ho... Read More about Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.

Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease (2019)
Journal Article

The fungus Lecanicillium fungicola causes dry bubble disease in the white button mushroom Agaricus bisporus. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this patho... Read More about Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease.

Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours (2019)
Journal Article

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers.... Read More about Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity (2019)
Journal Article

Three new polyketide-derived natural products, cladobotric acids G-I (1-3), and six known metabolites (4, 5, 8-11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spectroscop... Read More about Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity.