Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Satchwell, Timothy J.; Wright, Katherine E.; Haydn-Smith, Katy L.; Sánchez-Román Terán, Fernando; Moura, Pedro L.; Hawksworth, Joseph; Frayne, Jan; Toye, Ashley M.; Baum, Jake

doi:10.1038/s41467-019-11790-w

All Outputs (2)

Reticulocyte and red blood cell deformation triggers specific phosphorylation events (2019)
Journal Article

The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a... Read More about Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements (2019)
Journal Article

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent i... Read More about Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.